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神经重症专家对基于神经学标准判定的死亡及器官捐献的看法。

Neurointensivists' opinions about death by neurological criteria and organ donation.

作者信息

Boissy Adrienne R, Provencio J Javier, Smith Cheryl A, Diringer Michael N

机构信息

Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

出版信息

Neurocrit Care. 2005;3(2):115-21. doi: 10.1385/ncc:3:2:115.

DOI:10.1385/ncc:3:2:115
PMID:16174879
Abstract

INTRODUCTION

Neurointensivists are at the front line of treatment of patients who progress to death by neurological criteria (DNC). Although some of these patients will become organ donors, there has not been a systematic evaluation of the opinions and resources available to neurointensivists in regard to these important issues.

METHODS

We conducted a survey of neurointensivists regarding controversial issues in the declaration of DNC, procedures for discussing death and approaching donor families, and participation in donation after cardiac death (DCD).

RESULTS

The majority of centers described by the respondents had all five most commonly accepted ancillary tests to determine DNC (61%). Radionuclide blood flow studies are the most frequently reported test used (64%). Younger physicians are more likely to use trans-cranial Doppler exams (TCD) than their older counterparts (41% versus 28%, p<0.001). Discussions about DNC with the family are most often presided by the attending physician, and donation requests are most commonly initiated by organ procurement organization (OPO) representatives, but there is significant variation from center to center. Nine out of 10 physicians in our survey reported that they are likely to participate in DCD.

CONCLUSION

Despite this enthusiasm, there is no clear consensus on many of the issues surrounding DCD, including how long after cardiac cessation recovery should begin. We believe that this study will serve as a springboard for more discussion about the diagnosis of DNC, the role of physicians in organ requests and donor management, and the procurement of organs through DCD.

摘要

引言

神经重症专家处于按照神经学标准判定为脑死亡(DNC)患者治疗的前线。尽管其中一些患者会成为器官捐献者,但对于这些重要问题,尚未对神经重症专家可获得的意见和资源进行系统评估。

方法

我们针对神经重症专家开展了一项关于DNC判定中的争议问题、讨论死亡及与捐献者家属沟通的程序以及参与心脏死亡后捐献(DCD)情况的调查。

结果

受访者描述的大多数中心具备所有五项最常用的辅助检查来判定DNC(61%)。放射性核素血流研究是最常报告使用的检查(64%)。年轻医生比年长医生更有可能使用经颅多普勒检查(TCD)(41%对28%,p<0.001)。与家属关于DNC的讨论最常由主治医师主持,捐献请求最常见由器官获取组织(OPO)代表发起,但各中心之间存在显著差异。我们调查中的十分之九的医生报告称他们可能会参与DCD。

结论

尽管有这种积极性,但围绕DCD的许多问题尚无明确共识,包括心脏停搏后恢复应在多久后开始。我们认为这项研究将成为一个跳板,引发关于DNC诊断、医生在器官请求和供体管理中的作用以及通过DCD获取器官等问题的更多讨论。

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本文引用的文献

1
Ethical and legal issues in non-heart-beating organ donation.
Transplantation. 2005 May 15;79(9):1143-7. doi: 10.1097/01.tp.0000160761.86036.6c.
2
Organ donation and transplantation: a survey of critical care health professionals in nontransplant hospitals.器官捐赠与移植:对非移植医院重症监护医护人员的一项调查
Prog Transplant. 2005 Mar;15(1):69-77. doi: 10.1177/152692480501500112.
3
Role of brain death and the dead-donor rule in the ethics of organ transplantation.脑死亡和死亡供体规则在器官移植伦理中的作用。
Crit Care Med. 2003 Sep;31(9):2391-6. doi: 10.1097/01.CCM.0000090869.19410.3C.
4
Defining death in non-heart beating organ donors.非心脏跳动器官捐献者的死亡判定
J Med Ethics. 2003 Jun;29(3):182-5. doi: 10.1136/jme.29.3.182.
5
Non-heart beating organ donation: old procurement strategy--new ethical problems.非心脏跳动器官捐献:旧的获取策略——新的伦理问题。
J Med Ethics. 2003 Jun;29(3):176-81. doi: 10.1136/jme.29.3.176.
6
The physician's role in discussing organ donation with families.医生在与家属讨论器官捐献时的角色。
Crit Care Med. 2003 May;31(5):1568-73. doi: 10.1097/01.CCM.0000063090.21056.A6.
7
Pro/con ethics debate: is nonheart-beating organ donation ethically acceptable?支持/反对伦理辩论:非心脏跳动器官捐赠在伦理上是否可接受?
Crit Care. 2002 Jun;6(3):192-5. doi: 10.1186/cc1487. Epub 2002 Apr 26.
8
The Institute of Medicine's report on non-heart-beating organ transplantation.医学研究所关于非心脏跳动器官移植的报告。
Kennedy Inst Ethics J. 1998 Mar;8(1):83-90. doi: 10.1353/ken.1998.0003.
9
Recommendations for nonheartbeating organ donation. A position paper by the Ethics Committee, American College of Critical Care Medicine, Society of Critical Care Medicine.
Crit Care Med. 2001 Sep;29(9):1826-31. doi: 10.1097/00003246-200109000-00029.
10
Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage.入住神经科/神经外科重症监护病房与脑出血后死亡率降低相关。
Crit Care Med. 2001 Mar;29(3):635-40. doi: 10.1097/00003246-200103000-00031.