Lekakis John P, Papamichael Christos, Papaioannou Theodore G, Stamatelopoulos Kimon S, Cimponeriu Adriana, Protogerou Athanassios D, Kanakakis John, Stamatelopoulos Stamatios F
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, 11363, Athens, Greece.
Int J Cardiovasc Imaging. 2005 Oct;21(5):495-501. doi: 10.1007/s10554-004-8165-x.
In the present study we measured carotid and femoral intima-media thickness (IMT) by B-Mode ultrasonography, as well as angiographic extent and severity of coronary artery disease in patients referred for coronary arteriography, to assess the relation between individual IMT, scores incorporating IMT from the carotid and femoral arteries and the extent and severity of coronary artery disease.
Two hundred and two patients referred for elective coronary angiography underwent ultrasound imaging of both carotid and femoral arteries for IMT measurements. An IMT score was developed as the number of sites with abnormal IMT (range 0-8). Multiple regression analysis indicated that IMT score was independently related to Gensini score, age and glucose levels. A high risk IMT score predicted an extended coronary artery disease although a low or medium risk IMT score cannot exclude the possibility of multivessel disease. Also, a high risk group could predict the performance of revascularization procedures and all cardiovascular events during a follow-up of 14.5 +/- 2.4 months.
IMT incorporating data from common and internal carotid artery, carotid bifurcation and femoral artery are well correlated with the extent of coronary atherosclerosis, much better than individual IMT. Patients with high IMT score usually have multivessel coronary artery disease and are at increased risk for subsequent cardiovascular events.
在本研究中，我们通过B型超声测量了接受冠状动脉造影患者的颈动脉和股动脉内膜中层厚度（IMT），以及冠状动脉疾病的血管造影范围和严重程度，以评估个体IMT、包含颈动脉和股动脉IMT的评分与冠状动脉疾病范围和严重程度之间的关系。
202例接受择期冠状动脉造影的患者接受了颈动脉和股动脉的超声成像以测量IMT。IMT评分以IMT异常的部位数量计算（范围0 - 8）。多元回归分析表明，IMT评分与Gensini评分、年龄和血糖水平独立相关。高风险IMT评分预示冠状动脉疾病范围扩大，尽管低或中等风险IMT评分不能排除多支血管病变的可能性。此外，高风险组可预测在14.5±2.4个月随访期间血运重建手术的实施情况和所有心血管事件。
综合颈总动脉、颈内动脉、颈动脉分叉和股动脉数据的IMT与冠状动脉粥样硬化范围密切相关，比个体IMT相关性更好。IMT评分高的患者通常患有多支血管冠状动脉疾病，随后发生心血管事件的风险增加。
