Diez-Porres L, Rios-Blanco J J, Robles-Marhuenda A, Gutiérrez-Molina M, Gil-Aguado A, Vázquez-Rodríguez J J
Department of Internal Medicine, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Spain.
Lupus. 2005;14(8):632-4. doi: 10.1191/0961203305lu2153cr.
Coexistence of a vasculitis and a neoplastic disease is rare and the pathogenesis is unknown. Most of these associations refer to leukocytoclastic or poliarteritis nodosa (PAN)-type vasculitis and hematological malignancies. There are few reports of vasculitis in patients with solid tumours and there are also few reports of paraneoplastic ANCA-associated vasculitis. We report a case of p-ANCA-positive vasculitis with peripheral nerve involvement associated with a colon cancer. Vasculitis resolved after corticoid treatment and surgical removal of the tumour.
血管炎与肿瘤性疾病并存的情况较为罕见,其发病机制尚不清楚。这些关联大多涉及白细胞破碎性血管炎或结节性多动脉炎(PAN)型血管炎与血液系统恶性肿瘤。实体瘤患者发生血管炎的报道较少,副肿瘤性抗中性粒细胞胞浆抗体(ANCA)相关血管炎的报道也很少。我们报告一例与结肠癌相关的伴有周围神经受累的p-ANCA阳性血管炎病例。经皮质类固醇治疗及手术切除肿瘤后,血管炎得以缓解。