Neurology, All India Institute of Medical Sciences, New Delhi, India.
Neurology, All India Institute of Medical Sciences, New Delhi, India
BMJ Case Rep. 2023 Sep 11;16(9):e254397. doi: 10.1136/bcr-2022-254397.
Paraneoplastic neurological syndromes are immune-mediated neurological attacks triggered by malignancies. They are commonly associated with lung, breast, thymus, gynaecological and haematological malignancies. We report a case of a male patient in his late 40s with paraneoplastic encephalomyelitis due to a colonic adenocarcinoma emphasising a low threshold for extensive cancer evaluation in all subacutely presenting neurological syndromes. We also emphasise that the absence of a positive onconeural antibody does not preclude the diagnosis of a paraneoplastic syndrome.
副肿瘤性神经系统综合征是由恶性肿瘤引发的免疫介导性神经系统疾病。它们通常与肺部、乳腺、胸腺、妇科和血液系统恶性肿瘤相关。我们报告了一例 40 多岁男性患者，因结肠腺癌引起副肿瘤性脑脊髓炎，强调在所有亚急性出现的神经系统综合征中，都应低门槛进行广泛的癌症评估。我们还强调，即使存在神经抗体阴性也不能排除副肿瘤性综合征的诊断。
