2型糖尿病男性饮酒与血清硫酸脱氢表雄酮浓度之间的关联：与心血管风险降低的联系

Association between alcohol consumption and serum dehydroepiandrosterone sulphate concentration in men with Type 2 diabetes: a link to decreased cardiovascular risk.

作者信息

Fukui M, Kitagawa Y, Nakamura N, Kadono M, Hasegawa G, Yoshikawa T

机构信息

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

出版信息

Diabet Med. 2005 Oct;22(10):1446-50. doi: 10.1111/j.1464-5491.2005.01629.x.

DOI:10.1111/j.1464-5491.2005.01629.x

PMID:16176211

Abstract

AIMS

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with Type 2 diabetes. Both light-to-moderate alcohol consumption and higher serum concentrations of dehydroepiandrosterone (DHEA) are associated with reduced CVD mortality, raising the possibility of DHEA as a causal intermediate in CVD and alcohol consumption.

METHODS

Relationships between alcohol consumption and serum DHEA sulphate (DHEA-S) concentration, carotid atherosclerosis as evaluated by carotid ultrasonography and major cardiovascular risk factors were investigated in 404 consecutive men with Type 2 diabetes. Patients were divided into three groups according to mean ethanol consumption per week: non-drinkers, light-to-moderate drinkers (< 210 g per week) or heavy drinkers (> or = 210 g per week).

RESULTS

Plasma HDL-cholesterol was positively associated with the degree of alcohol consumption. Intima-media thickness (0.92 +/- 0.21 vs. 1.09 +/- 0.35 mm, P < 0.0001) and plaque score (3.0 +/- 3.3 vs. 5.2 +/- 4.9, P = 0.008) were lower in light-to-moderate drinkers than in non-drinkers. Serum DHEA-S concentrations were higher in light-to-moderate drinkers (1264.2 +/- 592.2 ng/ml, P < 0.0001) and heavy drinkers (1176.2 +/- 607.6 ng/ml, P = 0.0100) than in non-drinkers (956.8 +/- 538.6 ng/ml). In a subgroup aged 60-75-year-old patients (n = 277), serum DHEA-S concentrations were higher in light-to-moderate drinkers (1126.8 +/- 502.5 ng/ml, P = 0.0121) than in non-drinkers (937.9 +/- 505.1 ng/ml). Also, in a subgroup without CVD (n = 339), serum DHEA-S concentrations were higher in light-to-moderate drinkers (1328.5 +/- 593.7 ng/ml, P < 0.0001) than in non-drinkers (970.1 +/- 540.7 ng/ml).

CONCLUSIONS

Higher serum DHEA-S concentrations in light-to-moderate drinkers may represent part of the link between light-to-moderate alcohol consumption and lower CVD mortality.

摘要

目的

心血管疾病（CVD）是2型糖尿病患者死亡和发病的主要原因。轻度至中度饮酒以及较高的血清脱氢表雄酮（DHEA）浓度均与心血管疾病死亡率降低相关，这增加了DHEA作为心血管疾病与饮酒之间因果中间因素的可能性。

方法

对404例连续的2型糖尿病男性患者，研究了饮酒量与血清硫酸脱氢表雄酮（DHEA-S）浓度、通过颈动脉超声评估的颈动脉粥样硬化以及主要心血管危险因素之间的关系。根据每周平均乙醇摄入量将患者分为三组：不饮酒者、轻度至中度饮酒者（每周<210克）或重度饮酒者（每周≥210克）。

结果

血浆高密度脂蛋白胆固醇与饮酒程度呈正相关。轻度至中度饮酒者的内膜中层厚度（0.92±0.21对1.09±0.35毫米，P<0.0001）和斑块评分（3.0±3.3对5.2±4.9，P = 0.008）低于不饮酒者。轻度至中度饮酒者（1264.2±592.2纳克/毫升，P<0.0001）和重度饮酒者（1176.2±607.6纳克/毫升，P = 0.0100）的血清DHEA-S浓度高于不饮酒者（956.8±538.6纳克/毫升）。在60 - 75岁的亚组患者（n = 277）中，轻度至中度饮酒者的血清DHEA-S浓度（1126.8±502.5纳克/毫升，P = 0.0121）高于不饮酒者（937.9±505.1纳克/毫升）。此外，在无心血管疾病的亚组（n = 339）中，轻度至中度饮酒者的血清DHEA-S浓度（1328.5±593.7纳克/毫升，P<0.0001）高于不饮酒者（970.1±540.7纳克/毫升）。