Shanmugam K R, Ramakrishna C H, Mallikarjuna K, Reddy K Sathyavelu
Division of Molecular and Exercise Physiology, Department of Zoology, Sri Venkateswara University, Tirupati-517 502, A.P, India.
Indian J Nephrol. 2009 Jul;19(3):101-6. doi: 10.4103/0971-4065.57106.
Diabetes is a major threat to global public health, and the number of diabetic patients is rapidly increasing worldwide. Evidence suggests that oxidative stress is involved in the pathophysiology of diabetic complications and alcoholic diseases. The aim of this study is to find out the impact of alcohol on lipid metabolic profiles in kidney tissue under streptozotocin induced diabetic condition. No study has been reported so far on the effect of alcohol on diabetic condition and also with reference to lipid metabolic profiles. Hence, the present study has been designed to elucidate the impact of alcoholism on diabetic condition. Male wistar strain albino rats were randomly divided into four groups: control (saline treated) NC, alcohol-treated (At), diabetic control (DC), and alcohol-treated diabetic rats (D+At). In alcohol-treated diabetic rats, we observed high levels of MDA, total cholesterol, triglycerides, phospholipids and also high levels of blood glucose than other groups. Moreover, degenerative changes of renal cells in alcohol-treated diabetic group were maximized by administration of alcohol as evinced by histopathological examination. This study suggests that alcohol consumption could be an aggravation factor which contributes for the formation of free radicals in diabetic condition. Therefore, consumption of alcohol during diabetic condition is harmful.
糖尿病是对全球公共卫生的重大威胁，全球糖尿病患者数量正在迅速增加。有证据表明，氧化应激参与糖尿病并发症和酒精性疾病的病理生理过程。本研究的目的是探究在链脲佐菌素诱导的糖尿病状态下，酒精对肾脏组织脂质代谢谱的影响。目前尚无关于酒精对糖尿病状态以及脂质代谢谱影响的相关研究报道。因此，本研究旨在阐明酗酒对糖尿病状态的影响。雄性Wistar品系白化大鼠被随机分为四组：对照组（生理盐水处理）NC、酒精处理组（At）、糖尿病对照组（DC）以及酒精处理糖尿病大鼠组（D+At）。在酒精处理糖尿病大鼠组中，我们观察到丙二醛、总胆固醇、甘油三酯、磷脂水平以及血糖水平均高于其他组。此外，组织病理学检查表明，酒精处理糖尿病组肾细胞的退行性变化因酒精的给药而加剧。本研究表明，饮酒可能是糖尿病状态下自由基形成的一个加重因素。因此，糖尿病状态下饮酒有害。
