Fukui M, Ose H, Kitagawa Y, Kamiuchi K, Nakayama I, Ohta M, Obayashi H, Yamasaki M, Hasegawa G, Yoshikawa T, Nakamura N
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Diabet Med. 2007 Aug;24(8):864-71. doi: 10.1111/j.1464-5491.2007.02213.x. Epub 2007 Jun 25.
Metabolic syndrome is characterized by its association with certain cardiovascular disease risk factors. The aim of this study was to investigate the relationships between metabolic syndrome and markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes.
Using the 2005 International Diabetes Federation (IDF) definition, we assessed the prevalence of the metabolic syndrome in 424 consecutive men with Type 2 diabetes aged 40-75 years in a cross-sectional study. We compared characteristics including ultrasonographic carotid atherosclerosis markers, pulse-wave velocity (PWV), and serum adiponectin, free testosterone, and dehydroepiandrosterone sulphate (DHEA-S) concentrations in diabetic patients with and without the metabolic syndrome.
The prevalence of the metabolic syndrome in Japanese men with Type 2 diabetes was 46.9%. Men with the metabolic syndrome had higher urinary albumin excretion rate than those without. Carotid intima-media thickness (0.97 +/- 0.26 vs. 0.91 +/- 0.18 mm), plaque score [3.3 (1.5-8.1) vs. 3.8 (1.3-6.2)], PWV (1818 +/- 331 vs. 1749 +/- 331 cm/s) and ankle-brachial index (1.10 +/- 0.14 vs. 1.08 +/- 0.16) did not differ significantly between patients with and without the metabolic syndrome. Similarly, serum adiponectin [3.70 (2.06-6.09) vs. 4.65 (3.09-7.02) microg/ml], free testosterone (36.4 +/- 10.7 vs. 34.7 +/- 11.1 pmol/l), and DHEA-S concentrations (3.29 +/- 1.83 vs. 3.17 +/- 1.63 micromol/l) did not differ significantly between groups,
The metabolic syndrome, as defined by the IDF, is not significantly associated with subclinical atherosclerosis markers, serum adiponectin, or endogenous androgen concentrations in Japanese men with Type 2 diabetes.
代谢综合征的特征是与某些心血管疾病风险因素相关。本研究的目的是调查2型糖尿病日本男性中代谢综合征与亚临床动脉粥样硬化标志物、血清脂联素和内源性雄激素浓度之间的关系。
在一项横断面研究中，我们采用2005年国际糖尿病联盟（IDF）的定义，评估了424例年龄在40 - 75岁的2型糖尿病男性患者中代谢综合征的患病率。我们比较了有和没有代谢综合征的糖尿病患者的特征，包括超声颈动脉粥样硬化标志物、脉搏波速度（PWV）以及血清脂联素、游离睾酮和硫酸脱氢表雄酮（DHEA - S）浓度。
2型糖尿病日本男性中代谢综合征的患病率为46.9%。有代谢综合征的男性尿白蛋白排泄率高于无代谢综合征者。有和没有代谢综合征的患者之间，颈动脉内膜中层厚度（0.97±0.26对0.91±0.18mm）、斑块评分[3.3（1.5 - 8.1）对3.8（1.3 - 6.2）]、PWV（1818±331对1749±331cm/s）和踝臂指数（1.10±0.14对1.08±0.16）无显著差异。同样，有和没有代谢综合征的两组之间，血清脂联素[3.70（2.06 - 6.09）对4.65（3.09 - 7.02）μg/ml]、游离睾酮（36.4±10.7对34.7±11.1pmol/l）和DHEA - S浓度（3.29±1.83对3.17±1.63μmol/l）也无显著差异。
IDF定义的代谢综合征与2型糖尿病日本男性的亚临床动脉粥样硬化标志物、血清脂联素或内源性雄激素浓度无显著关联。
