Takizawa Daisuke, Saito Shigeru, Sato Eri, Hiraoka Haruhiko, Kunimoto Fumio, Goto Fumio
Department of Anesthesiology, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.
Fundam Clin Pharmacol. 2005 Oct;19(5):597-9. doi: 10.1111/j.1472-8206.2005.00351.x.
It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control and landiolol group. Induction of anesthesia commenced 10 min after the infusion of 0.9% saline or landiolol, using a Diprifusor set to achieve propofol plasma concentration of 6.0 microg/mL. Induction of anesthesia was defined as the first lack of response to command. Propofol dose was 2.22+/- 0.21 mg/kg for the control group and 1.79+/- 0.28 mg/kg for the landiolol group (P<0.0001). The quantity of propofol required for the induction of anesthesia was reduced by the administration of landiolol.
据报道，丙泊酚的药代动力学受心输出量（CO）影响。本研究的目的是评估兰地洛尔（短效β1肾上腺素能阻滞剂）对丙泊酚诱导麻醉所需剂量的影响。40例患者被随机分配至对照组和兰地洛尔组。在输注0.9%生理盐水或兰地洛尔10分钟后开始麻醉诱导，使用得普利麻注射泵使丙泊酚血浆浓度达到6.0微克/毫升。麻醉诱导定义为首次对指令无反应。对照组丙泊酚剂量为2.22±0.21毫克/千克，兰地洛尔组为1.79±0.28毫克/千克（P<0.0001）。给予兰地洛尔可减少诱导麻醉所需的丙泊酚量。
