Nakagawa M, Shirato K, Sakuma M, Ishigaki H, Ohe M, Ikeda J, Takishima T
Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Cathet Cardiovasc Diagn. 1992 Jul;26(3):185-91. doi: 10.1002/ccd.1810260305.
To evaluate the left ventricular contractile state in patients with nonobstructive hypertrophic cardiomyopathy (HCM), we analyzed the maximum stress-volume index ratio (MSVR) using catheter-tip cineangiography in 11 patients with HCM and 16 normal subjects. The value of the MSVR in normal subjects was 6.48 +/- 1.25 kdyn/cm5/m2 (mean +/- SD) and we defined the range of the mean +/- 2 SD as the normal MSVR range. Six patients with HCM placed inside the normal MSVR range (IN), but the other 5 patients placed outside and to the right of the normal range (RIGHT). This suggests that the contractile states of the patients of the RIGHT group were depressed. Compared with IN, the end-diastolic and end-systolic volume indices of RIGHT were larger (EDVI; 69.3 +/- 6.9 vs. 96.1 +/- 11.1 ml/m2, p less than 0.01, ESVI; 18.2 +/- 3.2 vs. 29.1 +/- 8.3 ml/m2, p less than 0.05), but the ejection fraction did not differ (IN 73.5 +/- 5.7 vs. RIGHT 69.6 +/- 8.3%, NS). End-diastolic pressure of IN and RIGHT was higher than that of normal subjects (IN 16.5 +/- 4.5, RIGHT 16.7 +/- 4.6 vs. 8.3 +/- 2.5 mm Hg, both p less than 0.05), but there was no difference between the two groups in HCM. End-systolic pressure did not differ among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
为评估非梗阻性肥厚型心肌病（HCM）患者的左心室收缩状态，我们采用导管顶端电影血管造影术分析了11例HCM患者和16名正常受试者的最大应力-容积指数比（MSVR）。正常受试者的MSVR值为6.48±1.25 kdyn/cm5/m2（均值±标准差），我们将均值±2标准差的范围定义为正常MSVR范围。6例HCM患者的MSVR值处于正常范围内（IN组），但另外5例患者的MSVR值超出正常范围且位于右侧（RIGHT组）。这表明RIGHT组患者的收缩状态受到抑制。与IN组相比，RIGHT组的舒张末期和收缩末期容积指数更大（舒张末期容积指数；69.3±6.9 vs. 96.1±11.1 ml/m2，p<0.01，收缩末期容积指数；18.2±3.2 vs. 29.1±8.3 ml/m2，p<0.05），但射血分数无差异（IN组73.5±5.7 vs. RIGHT组69.6±8.3%，无显著性差异）。IN组和RIGHT组的舒张末期压力高于正常受试者（IN组16.5±4.5，RIGHT组16.7±4.6 vs. 8.3±2.5 mmHg，p均<0.05），但HCM患者的这两组之间无差异。三组的收缩末期压力无差异。（摘要截短于250字）
