Ocampo Sandra M, Albericio Fernando, Fernández Irene, Vilaseca Marta, Eritja Ramon
Institut de Biologia Molecular de Barcelona, CSIC, Jordi Girona 18-26, E-08034 Barcelona, Spain.
Org Lett. 2005 Sep 29;7(20):4349-52. doi: 10.1021/ol0514698.
[reaction: see text] 5'-Peptide oligonucleotide conjugates were prepared stepwise on a single support using N(alpha)-Fmoc-protected amino acids and unprotected phosphate groups. The method uses commercially available reagents and is successful with most natural amino acids. The simplicity of the method may encourage researchers to prepare new oligonucleotide-peptide conjugates with novel properties.
