Nilsson Hans-Olof, Pietroiusti Antonio, Gabrielli Maurizio, Zocco Maria Assunta, Gasbarrini Giovanni, Gasbarrini Antonio
Department of Laboratory Medicine, Lund University, Lund, Sweden.
Helicobacter. 2005;10 Suppl 1:54-65. doi: 10.1111/j.1523-5378.2005.00334.x.
The involvement of Helicobacter pylori in the pathogenesis of extragastric diseases continues to be an interesting topic in the field of Helicobacter-related pathology. Although conflicting findings have been reported for most of the disorders, a role of H. pylori seems to be important especially for the development of cardiovascular and hematologic disorders. Previously isolated human and animal Helicobacter sp. flexispira and "Helicobacter heilmannii" strains have been validated using polyphasic taxonomy. A novel enterohepatic Helicobacter has been isolated from mastomys and mice, adding to the list of helicobacters that colonize the liver. Genetic targets that may aid the classification of novel Helicobacter species have emerged. Animal models of Helicobacter-induced gastric and hepatobiliary diseases have offered insights to the mechanisms associated with premalignant transformation.
幽门螺杆菌在胃外疾病发病机制中的作用仍是幽门螺杆菌相关病理学领域一个有趣的话题。尽管对于大多数疾病都有相互矛盾的研究结果报道，但幽门螺杆菌的作用似乎尤为重要，特别是在心血管和血液系统疾病的发生发展方面。先前分离出的人及动物幽门螺杆菌、屈曲螺杆菌和“海尔曼螺杆菌”菌株已通过多相分类法得到验证。从非洲沼鼠和小鼠中分离出一种新型肠肝螺杆菌，这增加了定殖于肝脏的螺杆菌种类。有助于新型幽门螺杆菌物种分类的基因靶点已经出现。幽门螺杆菌诱导的胃和肝胆疾病动物模型为与癌前病变相关的机制提供了见解。
