Parnas Josef, Handest Peter, Jansson Lennart, Saebye Ditte
Department of Psychiatry, Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark.
Psychopathology. 2005 Sep-Oct;38(5):259-67. doi: 10.1159/000088442. Epub 2005 Sep 20.
Our research group has for several years conducted philosophically informed, phenomenological-empirical studies of morbid alterations of conscious experience (subjectivity) in schizophrenia (Sz) and its spectrum of disorders. Some of these experiential alterations constitute, in our view, the vulnerability markers to Sz--indicators that are intrinsic to this disorder and which were historically considered as constituting the phenotypic anchor of the very concept and the diagnostic validity of Sz spectrum disorders. In a more pragmatic clinical context, these indicators, considered here as symptoms, may be potentially effective for early differential diagnosis. In this study, 151 consecutive first-admitted patients (with bipolar, melancholic and organic patients excluded) diagnosed according to the ICD-10, were evaluated on a number of expressive and experiential psychopathological dimensions, with special emphasis on the experiences of perplexity, disorders of self-awareness, perceptual disorders and anomalous bodily experiences. The a priori scales derived from the item pool of a slightly modified OPCRIT and BSABS were used for analyses. Sz and schizotypal disorder scored equally on the subjective dimensions, suggesting a basic phenomenological affinity of these disorders. In contrast, anomalies of subjective experience were clearly more pronounced among the patients within, as compared to those outside the Sz spectrum.
我们的研究小组多年来一直在进行基于哲学思考、现象学实证的研究,探讨精神分裂症(Sz)及其谱系障碍中意识体验(主观性)的病态改变。在我们看来,其中一些体验性改变构成了精神分裂症的易感性标志物——这些指标是该疾病所固有的,在历史上被认为构成了精神分裂症谱系障碍这一概念及其诊断有效性的表型锚定。在更实际的临床背景下,这里被视为症状的这些指标可能对早期鉴别诊断具有潜在效果。在本研究中,根据国际疾病分类第10版(ICD - 10)诊断的151例连续首次入院患者(排除双相情感障碍、忧郁症和器质性疾病患者),在多个表达性和体验性精神病理学维度上进行了评估,特别强调困惑体验、自我意识障碍、感知障碍和异常身体体验。从经过轻微修改的OPCRIT和BSABS项目库中得出的先验量表用于分析。精神分裂症和分裂型障碍在主观维度上得分相同,表明这些障碍在基本现象学上具有相似性。相比之下,与精神分裂症谱系之外的患者相比,精神分裂症谱系内患者的主观体验异常明显更为突出。