Kim Young-Mi, Lee Geon-Ho, Yeo Young-Geun, Kim In-Hwan, Miyashita Kazuo, Hou Ching T, Kang Sun-Chul, Kim Hak-Ryul
Department of Animal Science and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea.
J Ind Microbiol Biotechnol. 2006 Jan;33(1):17-21. doi: 10.1007/s10295-005-0037-4. Epub 2005 Sep 23.
Microbial modification of vegetable fatty acids can often lead to special changes in their structure and in biological function. A bacterial strain, Pseudomonas aeruginosa PR3, is known to carry out multiple hydroxylations on polyunsaturated fatty acids containing 1,4-cis, cis diene structural units, resulting in antibacterial activity. In this paper, in an effort to understand the overall mechanism involved in the varied biological functions of the complicated metabolites of bio-converted polyunsaturated fatty acids, we performed bioconversion of several polyunsaturated fatty acids using PR3, and determined their oxidative activities against fish oil. Bio-converted linoleic acid, eicosapentanoic acid, and docosahexanoic acid promoted effectively oxidation of fish oil. It is assumed that this oxidative effect could plausibly play an important role in the antimicrobial function of these bio-converted fatty acids.
