• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.

作者信息

Netzeva Tatiana I, Worth Andrew, Aldenberg Tom, Benigni Romualdo, Cronin Mark T D, Gramatica Paolo, Jaworska Joanna S, Kahn Scott, Klopman Gilles, Marchant Carol A, Myatt Glenn, Nikolova-Jeliazkova Nina, Patlewicz Grace Y, Perkins Roger, Roberts David, Schultz Terry, Stanton David W, van de Sandt Johannes J M, Tong Weida, Veith Gilman, Yang Chihae

机构信息

EVCAM, ECB, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy.

出版信息

Altern Lab Anim. 2005 Apr;33(2):155-73. doi: 10.1177/026119290503300209.

DOI:10.1177/026119290503300209
PMID:16180989
Abstract
摘要

相似文献

1
Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.（定量）构效关系适用性域定义方法的现状。欧洲替代方法验证中心（ECVAM）第52次研讨会的报告与建议
Altern Lab Anim. 2005 Apr;33(2):155-73. doi: 10.1177/026119290503300209.
2
The ECVAM workshops: a critical assessment of their impact on the development, validation and acceptance of alternative methods.欧洲替代方法验证中心研讨会：对其在替代方法的开发、验证及接受方面所产生影响的批判性评估
Altern Lab Anim. 2002 Dec;30 Suppl 2:151-65. doi: 10.1177/026119290203002S25.
3
Three Rs Approaches in Marine Biotoxin Testing. The Report and Recommendations of a joint ECVAM/DG SANCO Workshop (ECVAM Workshop 54).海洋生物毒素检测中的3R方法。欧洲替代方法验证中心/欧盟卫生与食品安全总司联合研讨会（欧洲替代方法验证中心第54号研讨会）报告及建议
Altern Lab Anim. 2006 May;34(2):193-224. doi: 10.1177/026119290603400207.
4
Novel advanced in vitro methods for long-term toxicity testing: the report and recommendations of ECVAM workshop 45. European Centre for the Validation of Alternative Methods.用于长期毒性测试的新型先进体外方法：欧洲替代方法验证中心第45期研讨会报告及建议
Altern Lab Anim. 2001 Jul-Aug;29(4):393-426. doi: 10.1177/026119290102900407.
5
The potential of physicochemical and immunochemical assays to replace animal tests in the quality control of toxoid vaccines. The report and recommendations of ECVAM workshop 61.物理化学和免疫化学检测方法在类毒素疫苗质量控制中替代动物试验的潜力。欧洲替代方法验证中心第61次研讨会的报告与建议
Altern Lab Anim. 2007 Jun;35(3):323-31. doi: 10.1177/026119290703500307.
6
The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM workshop 56.体外重复剂量毒性评估：一种提议的方法。欧洲替代方法验证中心第56次研讨会的报告与建议
Altern Lab Anim. 2006 Jun;34(3):315-41. doi: 10.1177/026119290603400307.
7
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.代谢：体外毒理学试验发展的一个瓶颈。欧洲替代方法验证中心（ECVAM）第54次研讨会的报告与建议
Altern Lab Anim. 2006 Feb;34(1):49-84. doi: 10.1177/026119290603400113.
8
The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58.测试方法和测试策略的证据权重验证原则。欧洲替代方法验证中心（ECVAM）第58次研讨会的报告与建议。
Altern Lab Anim. 2006 Dec;34(6):603-20. doi: 10.1177/026119290603400604.
9
Validation is a key theme in this issue of ALTEX.验证是本期《ALTEX》的一个关键主题。
ALTEX. 2011;28(1):1.
10
The current status and future applicability of quantitative structure-activity relationships (QSARs) in predicting toxicity.定量构效关系（QSARs）在预测毒性方面的现状及未来适用性。
Altern Lab Anim. 2002 Dec;30 Suppl 2:81-4. doi: 10.1177/026119290203002S12.

引用本文的文献

1
AI-based nanotoxicity data extraction and prediction of nanotoxicity.基于人工智能的纳米毒性数据提取与纳米毒性预测
Comput Struct Biotechnol J. 2025 Apr 3;29:138-148. doi: 10.1016/j.csbj.2025.03.052. eCollection 2025.
2
Nanoparticle Skin Penetration: Depths and Routes Modeled In-Silico.纳米颗粒的皮肤渗透：计算机模拟的深度和途径
Small. 2025 May;21(20):e2412541. doi: 10.1002/smll.202412541. Epub 2025 Mar 27.
3
A data-driven generative strategy to avoid reward hacking in multi-objective molecular design.一种数据驱动的生成策略，用于避免多目标分子设计中的奖励操纵。
Nat Commun. 2025 Mar 11;16(1):2409. doi: 10.1038/s41467-025-57582-3.
4
Chemical feature-based machine learning model for predicting photophysical properties of BODIPY compounds: density functional theory and quantitative structure-property relationship modeling.用于预测BODIPY化合物光物理性质的基于化学特征的机器学习模型：密度泛函理论和定量结构-性质关系建模
J Mol Model. 2024 Dec 12;31(1):18. doi: 10.1007/s00894-024-06240-4.
5
Predicting the acute aquatic toxicity of organic UV filters used in cosmetic formulations.预测化妆品配方中使用的有机紫外线过滤剂的急性水生毒性。
ADMET DMPK. 2024 Sep 11;12(5):781-796. doi: 10.5599/admet.2364. eCollection 2024.
6
Modeling High Energy Molecules and Screening to Find Novel High Energy Candidates.高能分子建模与筛选以寻找新型高能候选物。
ACS Omega. 2024 Oct 11;9(42):42709-42720. doi: 10.1021/acsomega.4c01070. eCollection 2024 Oct 22.
7
A Machine Learning Algorithm Suggests Repurposing Opportunities for Targeting Selected GPCRs.机器学习算法提示了针对特定 GPCR 靶向的再利用机会。
Int J Mol Sci. 2024 Sep 23;25(18):10230. doi: 10.3390/ijms251810230.
8
Applicability Domain for Trustable Predictions.可信赖预测的适用域。
Methods Mol Biol. 2025;2834:131-149. doi: 10.1007/978-1-0716-4003-6_6.
9
In Silico Insights: QSAR Modeling of TBK1 Kinase Inhibitors for Enhanced Drug Discovery.计算机模拟洞察：TBK1 激酶抑制剂的定量构效关系建模以增强药物发现。
J Chem Inf Model. 2024 Oct 14;64(19):7488-7502. doi: 10.1021/acs.jcim.4c00864. Epub 2024 Sep 17.
10
Prediction of Endocrine-Disrupting Chemicals Related to Estrogen, Androgen, and Thyroid Hormone (EAT) Modalities Using Transcriptomics Data and Machine Learning.利用转录组学数据和机器学习预测与雌激素、雄激素和甲状腺激素（EAT）模式相关的内分泌干扰化学物质
Toxics. 2024 Jul 26;12(8):541. doi: 10.3390/toxics12080541.