坦桑尼亚和挪威的性传播疾病患者、健康孕妇、献血者及医学生中单纯疱疹病毒2型抗体的流行情况及危险因素
Prevalence of, and risk factors for, HSV-2 antibodies in sexually transmitted disease patients, healthy pregnant females, blood donors and medical students in Tanzania and Norway.
作者信息
Nilsen A, Mwakagile D, Marsden H, Langeland N, Matre R, Haarr L
机构信息
Department of Dermatology, Institute of Medicine, Haukeland University Hospital, University of Bergen, Norway.
出版信息
Epidemiol Infect. 2005 Oct;133(5):915-25. doi: 10.1017/S095026880500395X.
The prevalence of specific HSV-2 antibodies was studied in Tanzanian and Norwegian sexually transmitted disease (STD) patients (1095) and non-STD patients (488). Correlates to demographic and behavioural factors were evaluated. Seropositivity was determined by the non-commercial peptide-55 enzyme-linked immunoassay. The prevalence of HSV-2 antibodies was 70% in Tanzanian and 17% in Norwegian STD patients, 35% in Tanzanian blood donors and pregnant women, and 4, 7 and 14% in Norwegian medical students, blood donors and pregnant women respectively. A higher HSV-2 prevalence was associated with female sex, increasing age, previous STDs, history of genital HSV infection, coitarchal age (age at first intercourse) <15 years and HIV seropositivity. Compared to previous data, the prevalence of HSV-2 antibodies in Tanzanian STD patients has increased remarkably. In Norwegian STD patients our results are consistent with, or lower than, the prevalence previously reported in Western Europe. Demographic rather than behavioural factors were associated with higher prevalence of HSV-2 antibodies in STD patients.
在坦桑尼亚和挪威的性传播疾病（STD）患者（1095例）和非STD患者（488例）中研究了特定HSV - 2抗体的流行情况。评估了与人口统计学和行为因素的相关性。血清阳性通过非商业性肽 - 55酶联免疫测定法确定。坦桑尼亚STD患者中HSV - 2抗体的流行率为70%，挪威STD患者中为17%；坦桑尼亚献血者和孕妇中为35%，挪威医学生、献血者和孕妇中分别为4%、7%和14%。HSV - 2流行率较高与女性、年龄增长、既往STD、生殖器HSV感染史、初潮年龄（首次性交年龄）<15岁以及HIV血清阳性有关。与先前数据相比，坦桑尼亚STD患者中HSV - 2抗体的流行率显著增加。在挪威STD患者中，我们的结果与西欧先前报道的流行率一致或更低。在STD患者中，人口统计学因素而非行为因素与HSV - 2抗体较高的流行率相关。
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