Aurangzeb Brekhna, Nisar Yasir Bin, Hazir Tabish, Burki Fayyaz, Hassan Mumtaz
Isolation Ward, The Children's Hospital, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan.
J Coll Physicians Surg Pak. 2005 Sep;15(9):547-51.
To determine the association of clinical outcome of measles in children with demographic profile and complications.
A cross-sectional analytical study.
Isolation ward, The Children's Hospital, Pakistan Institute of Medical Sciences (PIMS), from January 2003 to August 2004.
Detailed history and physical examination of all the hospitalized patients with complications of measles was filled in case report form. Immunization cards were assessed for measles vaccination status. Data was analyzed by using SPSS version 10 software. The clinical outcome of measles was compared with demographic profile and complications by using Chi-square test and p-values were obtained.
Two hundred and five hospitalized patients with complications of measles were studied. There were 61.5% males. Mean age was 46.1 months and 57% patients were vaccinated against measles. Malnourished patients were 71.2% and had a longer hospital stay (p=0.010). Pneumonia (40.0%) and diarrhoea (38.5%) were the commonest complications. Seven children died. Mortality was significantly associated with younger age (p=0.04), unvaccinated status (p=0.04) and presence of encephalitis (p=0.00001).
The most common complications of measles are pneumonia and diarrhoea with dehydration requiring hospitalization. Malnourished children experience more complications and have longer hospital stay. Mortality is significantly associated with infancy, unvaccinated status and encephalitis. A second dose of measles should be introduced at 15 months of age.
确定儿童麻疹临床结局与人口统计学特征及并发症之间的关联。
一项横断面分析研究。
2003年1月至2004年8月，巴基斯坦医学科学研究所儿童医院隔离病房。
将所有患有麻疹并发症的住院患者的详细病史和体格检查信息填入病例报告表。评估免疫接种卡以确定麻疹疫苗接种状况。使用SPSS 10版软件进行数据分析。通过卡方检验比较麻疹的临床结局与人口统计学特征及并发症，并得出p值。
对205例患有麻疹并发症的住院患者进行了研究。男性占61.5%。平均年龄为46.1个月，57%的患者接种过麻疹疫苗。营养不良患者占71.2%，住院时间更长（p = 0.010）。肺炎（40.0%）和腹泻（38.5%）是最常见的并发症。7名儿童死亡。死亡率与年龄较小（p = 0.04）、未接种疫苗（p = 0.04）以及存在脑炎（p = 0.00001）显著相关。
麻疹最常见的并发症是肺炎和腹泻伴脱水，需要住院治疗。营养不良的儿童并发症更多，住院时间更长。死亡率与婴儿期、未接种疫苗状态和脑炎显著相关。应在15月龄时接种第二剂麻疹疫苗。
