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The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer?

作者信息

Horwitz K B

机构信息

Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.

出版信息

Endocr Rev. 1992 May;13(2):146-63. doi: 10.1210/edrv-13-2-146.

DOI:10.1210/edrv-13-2-146
PMID:1618161
Abstract
摘要

相似文献

1
The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer?RU486的分子生物学。抗孕激素在乳腺癌治疗中是否有作用？
Endocr Rev. 1992 May;13(2):146-63. doi: 10.1210/edrv-13-2-146.
2
The anti-progestin RU486 stabilizes the progestin-induced fatty acid synthetase mRNA but does not stimulate its transcription.抗孕激素RU486可使孕激素诱导的脂肪酸合成酶信使核糖核酸稳定，但不会刺激其转录。
J Biol Chem. 1991 May 5;266(13):8220-4.
3
The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors.类固醇拮抗剂RU486对糖皮质激素受体和孕酮受体具有不同的作用。
Endocrinology. 1993 Aug;133(2):728-40. doi: 10.1210/endo.133.2.8344212.
4
Combined effects of RU486 and tamoxifen on the growth and cell cycle phases of the MCF-7 cell line.米非司酮和他莫昔芬对MCF-7细胞系生长及细胞周期各阶段的联合作用
J Clin Endocrinol Metab. 1992 Sep;75(3):865-70. doi: 10.1210/jcem.75.3.1517379.
5
RU 486 research forges on, despite political hurdles.
Scientist. 1994 Jan 24;8(2):14-5.
6
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.RU486拮抗作用的机制取决于人孕酮受体羧基末端尾巴的构象。
Cell. 1992 May 15;69(4):703-13. doi: 10.1016/0092-8674(92)90234-4.
7
New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP.用于独立研究孕酮B受体和A受体的新型T47D乳腺癌细胞系：只有抗孕激素占据的B受体可被cAMP转换为转录激动剂。
Cancer Res. 1994 Jul 15;54(14):3868-77.
8
Regression of uterine leiomyomata in response to the antiprogesterone RU 486.抗孕激素RU 486作用下子宫平滑肌瘤的消退
J Clin Endocrinol Metab. 1993 Feb;76(2):513-7. doi: 10.1210/jcem.76.2.8432797.
9
Antiprogestins: the political chemistry of RU486.抗孕激素：RU486的政治化学
Fertil Steril. 1991 Sep;56(3):394-5. doi: 10.1016/s0015-0282(16)54528-2.
10
Administration of RU 486 for 8 days in normal volunteers: antiglucocorticoid effect with no evidence of peripheral cortisol deprivation.正常志愿者连续8天服用RU 486：具有抗糖皮质激素作用，且无外周皮质醇缺乏的证据。
J Clin Endocrinol Metab. 1994 Feb;78(2):375-80. doi: 10.1210/jcem.78.2.8106625.

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