Suzan-Monti M, La Scola B, Raoult D
Unité des Rickettsies et Pathogènes Emergents, Faculté de Médecine, IFR 48, CNRS UMR 6020, Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France.
Virus Res. 2006 Apr;117(1):145-55. doi: 10.1016/j.virusres.2005.07.011. Epub 2005 Sep 21.
We recently described a giant double stranded DNA virus called Mimivirus, isolated from amoebae, which might represent a new pneumonia-associated human pathogen. Its unique morphological and genomic characteristics allowed us to propose Mimivirus as a member of a new distinct Nucleocytoplasmic Large DNA viruses family, the Mimiviridae. Mimivirus-specific features, namely its size and its genomic complexity, ranged it between viruses and cellular organisms. This paper reviews our current knowledge on Mimivirus structure, life cycle and genome analysis and discusses its putative evolutionary origin in the tree of species of the three domains of life.
我们最近描述了一种从变形虫中分离出的名为米米病毒的巨型双链DNA病毒，它可能是一种与肺炎相关的新型人类病原体。其独特的形态和基因组特征使我们能够提出将米米病毒作为一个新的独特的核质大DNA病毒家族——米米病毒科的成员。米米病毒的特异性特征，即其大小和基因组复杂性，使其介于病毒和细胞生物体之间。本文综述了我们目前对米米病毒结构、生命周期和基因组分析的认识，并讨论了其在生命三域物种树中的假定进化起源。
