García-Vallvé Santiago, Alonso Angel, Bravo Ignacio G
Evolutionary Genomics Group, Biochemistry and Biotechnology Department, Rovira i Virgili University (URV), c/ Marcel-li Domingo, s/n. Campus Sescelades, 43007 Tarragona, Spain.
Trends Microbiol. 2005 Nov;13(11):514-21. doi: 10.1016/j.tim.2005.09.003. Epub 2005 Sep 21.
Papillomaviruses (PVs) infect stratified squamous epithelia in vertebrates. Some PVs are associated with different types of cancer and with certain benign lesions. It has been assumed that PVs coevolved with their hosts. However, recently it has been shown that different regions of the genome have different evolutionary histories. The PV genome has a modular nature and appeared after the addition of pre-existent blocks. This order of appearance in the PV genome is evident today in the different evolutionary rates of the different genes, with new genes--E5, E6 and E7--diverging faster than old genes--E1, E2, L2 and L1. Here, we propose an evolutionary framework aiming to integrate genome evolution, PV biology and epidemiology of PV infections.
乳头瘤病毒（PVs）感染脊椎动物的复层鳞状上皮。一些PVs与不同类型的癌症及某些良性病变相关。人们一直认为PVs与其宿主共同进化。然而，最近有研究表明，基因组的不同区域有着不同的进化历史。PV基因组具有模块化性质，是在已有模块添加之后出现的。如今，PV基因组中这种出现顺序在不同基因的不同进化速率中很明显，新基因——E5、E6和E7——的分化速度比旧基因——E1、E2、L2和L1——更快。在此，我们提出一个进化框架，旨在整合基因组进化、PV生物学及PV感染的流行病学。
