Ding Biao, Itaya Asuka, Zhong Xuehua
Department of Plant Cellular and Molecular Biology and Plant Biotechnology Center, 207 Rightmire Hall, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA.
Curr Opin Plant Biol. 2005 Dec;8(6):606-12. doi: 10.1016/j.pbi.2005.09.001. Epub 2005 Sep 21.
RNA trafficking has broad implications in the systemic spread of infectious agents, plant defense, and the systemic regulation of gene expression. The mechanisms that regulate trafficking remain poorly understood. The non-coding, infectious viroid RNAs are emerging as highly tractable model systems for the investigation of the basic mechanisms of RNA trafficking. Recent studies on viroids have led to new insights into the direct role of RNAs in intracellular and systemic trafficking, and to the identification of cellular proteins that might play a role in RNA trafficking. Here, we discuss these areas of progress, emphasizing on the unifying principles that control the trafficking of viroid, viral and endogenous RNAs.
RNA转运在感染因子的系统性传播、植物防御以及基因表达的系统性调控中具有广泛影响。调控RNA转运的机制仍知之甚少。非编码感染性类病毒RNA正成为研究RNA转运基本机制的极具可操作性的模型系统。最近关于类病毒的研究为RNA在细胞内和系统性转运中的直接作用带来了新见解，并鉴定出可能在RNA转运中发挥作用的细胞蛋白。在此，我们讨论这些进展领域，重点强调控制类病毒、病毒和内源性RNA转运的统一原则。
