对听源性惊厥敏感和不敏感的WAG/Rij大鼠的行为特征
Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures.
作者信息
Sarkisova K Yu, Kulikov M A
机构信息
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerov str. 5A, Moscow 117485, Russia.
出版信息
Behav Brain Res. 2006 Jan 6;166(1):9-18. doi: 10.1016/j.bbr.2005.07.024. Epub 2005 Sep 23.
Some rats of the WAG/Rij (Wistar Albino Glaxo from Rijswijk) and Wistar strain are susceptible for audiogenic (convulsive) seizures. In the present study, behavior of susceptible and non-susceptible rats from the WAG/Rij strain, genetically predisposed to absence epilepsy, and outbred Wistar strain, genetically not predisposed to absence epilepsy, was compared to assess the level of anxiety (in the open field, light-dark choice and elevated plus-maze tests) and the level of depression (in the sucrose consumption and forced swimming tests). Increased level of anxiety was found only in audiogenic susceptible rats both from WAG/Rij and Wistar strain, but increased level of depression was found only in WAG/Rij rats independently of their susceptibility to audiogenic seizures. The results suggest that enhanced level of depression in WAG/Rij strain rats is associated with absence epilepsy but enhanced level of anxiety with susceptibility to audiogenic seizures.
一些WAG/Rij（来自赖斯韦克的Wistar白化病Glaxo）和Wistar品系的大鼠易发生听源性（惊厥性）癫痫发作。在本研究中，对来自WAG/Rij品系（具有失神癫痫的遗传易感性）的易感性和非易感性大鼠以及来自远交Wistar品系（无失神癫痫的遗传易感性）的大鼠的行为进行了比较，以评估焦虑水平（在旷场试验、明暗选择试验和高架十字迷宫试验中）和抑郁水平（在蔗糖消耗试验和强迫游泳试验中）。仅在来自WAG/Rij和Wistar品系的听源性易感大鼠中发现焦虑水平升高，但仅在WAG/Rij大鼠中发现抑郁水平升高，而与它们对听源性癫痫发作的易感性无关。结果表明，WAG/Rij品系大鼠抑郁水平的升高与失神癫痫有关，但焦虑水平的升高与听源性癫痫发作的易感性有关。
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