Lee Kemba N, Hutson Christina L, Kline Richard, Curns Aaron T, Dougherty Cindy, Allen Chris, Damon Inger, Regnery Russell
Poxvirus Program, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Vaccine. 2006 Feb 13;24(7):884-6. doi: 10.1016/j.vaccine.2005.08.079. Epub 2005 Sep 8.
Two distinct smallpox vaccine formulations were exposed to temperatures beyond the ranges specified by the manufacturers for vaccine maintenance and shipping. Under the conditions investigated, titers of both Dryvax smallpox vaccine and Aventis Pasteur smallpox vaccine remained at or above the titers recommended for successful vaccination. From these data it can be inferred that vaccine efficacy would not be expected to be adversely affected by unintended fluctuations of temperature, within the ranges studied, for a 4-day period.
