Trattnig S, Pinker K, Krestan C, Plank C, Millington S, Marlovits S
Department of Radiology, University Hospital of Vienna, Medical University of Vienna, Austria.
Eur J Radiol. 2006 Jan;57(1):9-15. doi: 10.1016/j.ejrad.2005.08.006. Epub 2005 Sep 23.
Monitoring of articular cartilage repair after matrix-associated autologous chondrocyte implantation with HyalograftC by a new grading system based on non-invasive high-resolution magnetic resonance imaging.
In 23 patients, postoperative magnetic resonance imaging (MRI) was performed between 76 and 120 weeks. In nine of these patients, five MRI examinations were performed at 4, 12, 24, 52 and 104 weeks after HyalograftC implant. The repair tissue was described with separate variables: degree of defect repair in width and length, signal intensity of the repair tissue and status of the subchondral bone. For these variables a grading system with point scale evaluation was applied.
High-resolution MRI provides a non-invasive tool for monitoring the development of cartilage repair tissue following HyalograftC technology, shows a good correlation with clinical outcome and may help to differentiate abnormal repair tissue from a normal maturation process.
通过基于非侵入性高分辨率磁共振成像的新分级系统，监测使用HyalograftC进行基质相关自体软骨细胞植入术后的关节软骨修复情况。
23例患者在术后76至120周进行了磁共振成像（MRI）检查。其中9例患者在植入HyalograftC后的4、12、24、52和104周进行了5次MRI检查。用不同变量描述修复组织：缺损修复的宽度和长度程度、修复组织的信号强度以及软骨下骨的状态。针对这些变量应用了带评分评估的分级系统。
高分辨率MRI为监测HyalograftC技术后软骨修复组织的发育提供了一种非侵入性工具，与临床结果具有良好的相关性，并且可能有助于区分异常修复组织与正常成熟过程。
