Kobayashi N, Takenouchi T, Endo S, Munekata E
Institute of Applied Biochemistry, University of Tsukuba, Japan.
FEBS Lett. 1992 Jun 29;305(2):105-9. doi: 10.1016/0014-5793(92)80874-g.
The conformation of bacitracin A, a widely used cyclic dodecapeptide antibiotic in aqueous solution, has been investigated using 500 MHz 1H NMR and molecular modeling. Findings revealed that a region (residues 1-6) is folded over the cyclic ring, resulting in metal coordination sites, a thiazoline ring, and Glu4 and His10 being proximate to each other.
