Vukelić M, Sostarić B, Belicza M
Medical Centre, Slavonski Brod, Croatia.
Food Chem Toxicol. 1992 Mar;30(3):193-200. doi: 10.1016/0278-6915(92)90033-h.
Within the county of Slavonski Brod, Yugoslavia hyperendemic areas of Balkan endemic nephropathy (BEN) have been recognized for a long time. As the Department of Pathology and Forensic Medicine of the Medical Centre in Slavonski Brod is responsible for all diagnostic post-mortem examinations in the county, and at the same time is engaged in surgical pathological diagnosis, a considerable amount of material relating to BEN and concomitant urinary-tract tumours has been collected during a 16-year period. This material has been classified and used for pathological, anatomical and histological investigations. In this paper the most relevant findings are described and briefly discussed, without the intention to speculate on possible aetiology of BEN. As the origin of BEN and of the high frequency of urinary tumours among the people from the endemic areas are still unexplained, and uniform criteria for the pathomorphological diagnosis of BEN are badly needed, the proposal to set up an archive encompassing cases from all the centres investigating BEN is supported.
在南斯拉夫的斯拉沃尼亚布罗德县，巴尔干地方性肾病（BEN）的高度流行区早已为人所知。由于斯拉沃尼亚布罗德医疗中心的病理与法医学系负责该县所有的诊断性尸检，同时也从事外科病理诊断，因此在16年的时间里收集了大量与BEN及伴发的尿路肿瘤相关的材料。这些材料已进行分类，并用于病理、解剖和组织学研究。本文描述并简要讨论了最相关的研究结果，无意推测BEN可能的病因。由于BEN的起源以及流行区人群中尿路肿瘤的高发病率仍无法解释，而且急需统一的BEN病理形态学诊断标准，因此支持建立一个包含所有研究BEN的中心病例的档案库这一提议。
