Soerjomataram I, Louwman W J, de Vries E, Lemmens V E P P, Klokman W J, Coebergh J W W
Netherlands Institute of Health Sciences, Rotterdam, The Netherlands.
Breast Cancer Res Treat. 2005 Sep;93(1):91-5. doi: 10.1007/s10549-005-4016-2.
To assess the risk of second primary cancers among women with previous breast cancer and calculate the excess burden of second cancer in the population.
A population-based longitudinal study was conducted using the Eindhoven cancer registry data on 9919 breast cancer patients diagnosed in the period 1972-2000 and followed until 2001. Standardised incidence ratios (SIR) and absolute excess risks (AER) were calculated.
In total, 1298 (13%) women developed a second primary cancer. The risk of overall second cancer was higher among breast cancer patients compared to the general population (SIR: 2.8; 95% CI: 2.6-2.9), with an AER of 115 second cancers for every 10,000 breast cancer patients per year. High SIR and AER were observed for breast cancer (SIR: 4.1; 95% CI: 3.8-4.4; AER: 64/10,000 patients/year) and ovarian cancer (SIR: 2.0; 95% CI: 1.5-2.7; AER: 4.5/10,000 patients/year).
Our recent data show that women with previous breast cancer have an elevated risk of developing a second cancer compared to the general population. Excess burden for the population is especially high for second cancers of the breast, ovary and colon. Screening may only be justified for breast, ovary and colon cancer in certain groups of patients.
评估既往患乳腺癌女性发生第二原发性癌症的风险，并计算人群中第二癌症的额外负担。
利用埃因霍温癌症登记处的数据进行了一项基于人群的纵向研究，该数据涉及1972年至2000年期间确诊的9919例乳腺癌患者，并随访至2001年。计算标准化发病率（SIR）和绝对超额风险（AER）。
共有1298名（13%）女性发生了第二原发性癌症。与普通人群相比，乳腺癌患者发生总体第二癌症的风险更高（SIR：2.8；95%置信区间：2.6 - 2.9），每年每10000名乳腺癌患者中有115例发生第二癌症的AER。乳腺癌（SIR：4.1；95%置信区间：3.8 - 4.4；AER：64/10000患者/年）和卵巢癌（SIR：2.0；95%置信区间：1.5 - 2.7；AER：4.5/10000患者/年）的SIR和AER较高。
我们的最新数据表明，与普通人群相比，既往患乳腺癌的女性发生第二癌症的风险升高。对于乳腺癌、卵巢癌和结肠癌的第二癌症，人群的额外负担尤其高。在某些患者群体中，仅对乳腺癌、卵巢癌和结肠癌进行筛查可能是合理的。
