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全血中某些热不稳定苯二氮䓬类药物的定量液相色谱、热喷雾/串联质谱（LC/TSP/MS/MS）分析。

Quantitative liquid chromatography, thermospray/tandem mass spectrometry (LC/TSP/MS/MS) analysis of some thermolabile benzodiazepines in whole-blood.

作者信息

Verweij A M, Lipman P J, Zweipfenning P G

机构信息

Department of General Chemistry, Ministry of Justice, Rijswijk, The Netherlands.

出版信息

Forensic Sci Int. 1992 Apr;54(1):67-74. doi: 10.1016/0379-0738(92)90081-7.

DOI:10.1016/0379-0738(92)90081-7
PMID:1618455
Abstract

An LC/TSP/MS/MS selected reaction monitoring (SRM) method in the daughter ion scan mode can be applied successfully for the quantitative determination of thermolabile benzodiazepines in whole-blood following an Extrelut extraction method. Detection limits as low as 100 pg per injection can be reached for all benzodiazepines. The benzodiazepines under investigation proved to be stable, with the exception of ketazolam for which complete degradation to diazepam was observed.

摘要

采用Extrelut萃取法后，在子离子扫描模式下的液相色谱/热喷雾串联质谱选择反应监测（SRM）方法可成功应用于全血中热不稳定苯二氮䓬类药物的定量测定。所有苯二氮䓬类药物的检测限可达每次进样低至100皮克。除观察到氯氮䓬完全降解为地西泮外，所研究的苯二氮䓬类药物均证明是稳定的。

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