Silhár Peter, Pohl Radek, Votruba Ivan, Hocek Michal
Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic.
Org Biomol Chem. 2005 Aug 21;3(16):3001-7. doi: 10.1039/b508122j. Epub 2005 Jul 4.
Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(fluoromethyl)purine ribonucleoside displayed significant cytostatic effects.
本文描述了两种合成新型6-(氟甲基)嘌呤碱基和核苷的替代方法，即通过直接脱氧氟化或从6-(羟甲基)嘌呤开始进行多步官能团转化。6-(氟甲基)嘌呤核糖核苷显示出显著的细胞生长抑制作用。
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