嘌呤修饰的 2'-C-甲基核苷的合成作为潜在的抗 HCV 药物。
Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
机构信息
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034. Epub 2011 Sep 20.
Abstract
Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.
摘要
基于 2'-C-甲基腺苷和 2'-C-甲基鸟苷的抗肝炎 C 活性，我们制备了一系列新型修饰嘌呤 2'-C-甲基核苷作为潜在的抗肝炎 C 病毒药物。在此，我们报告了 6 位修饰和 2 位修饰嘌呤 2'-C-甲基核苷的合成及其在不同细胞中抗 HCV 复制活性和细胞毒性。
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