Facile and efficient synthesis of 6-(hydroxymethyl)purines.
作者信息
Silhár Peter, Pohl Radek, Votruba Ivan, Hocek Michal
机构信息
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.
出版信息
Org Lett. 2004 Sep 16;6(19):3225-8. doi: 10.1021/ol049059r.
PMID:15355018
Abstract
[reaction: see text] A facile and efficient methodology of the synthesis of 6-(hydroxymethyl)purine derivatives (bases and nucleosides) was developed based on Pd-catalyzed cross-coupling reactions of 6-halopurines with acyloxymethylzinc iodides followed by deprotection. Several title compounds are inhibitors of adenosine deaminase and exert cytostatic activity.
摘要
Zotero 插件