[猪黏膜下层移植物用于治疗犬十二指肠损伤]
[Porcine submucosa graft for the treatment of duodenal injuries in dogs].
作者信息
Souza Filho Zacarias Alves de, Greca Fernando Hintz, Rocha Sergio Luiz, Ioshii Sergio Ossamu, Domanski Ana Carolina, Kfouri Diogo, Campos Priscila Dall Prá, Silva Ruy Fernando Kuenzer Caetano da
机构信息
Programa de Pós Graduação em Clínica Cirúrgica, Pontifícia Universidade Católica do Paraná.
出版信息
Acta Cir Bras. 2005 Sep-Oct;20(5):394-8. doi: 10.1590/s0102-86502005000500010. Epub 2005 Sep 5.
PURPOSE
To evaluate the biocompatibility and effectiveness of porcine SIS (small intestinal submucosa), when used as a patch to repair a defect on the anterior duodenal wall.
METHODS
The experimental study was performed in 8 dogs. A segment of the anterior duodenal wall was removed and the defect was repaired with a patch of porcine intestinal submucosa. On the 120th post operative day the animals were sacrificed and the segment of duodenum containing the patch was removed to a macroscopic and microscopic evaluation.
RESULTS
There was no infection, suture dehiscence or fistula. The microscopic evaluation showed complete re-epithelization in 75% of the cases, with moderate fibroblastic proliferation in 87.5% of the cases.
CONCLUSION
The porcine SIS used as a patch acts as a tissue substitute for repairing induced lesions in duodenal wall of dogs.
目的
评估猪小肠黏膜下层（SIS）用作修补十二指肠前壁缺损补片时的生物相容性和有效性。
方法
对8只犬进行实验研究。切除一段十二指肠前壁，用猪小肠黏膜下层补片修补缺损。术后第120天处死动物，取出含补片的十二指肠段进行大体和显微镜评估。
结果
未发生感染、缝线裂开或瘘管形成。显微镜评估显示，75%的病例实现完全再上皮化，87.5%的病例有中度成纤维细胞增生。
结论
用作补片的猪SIS可作为组织替代物，用于修复犬十二指肠壁的诱导性损伤。
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