Kirisci Levent, Vanyukov Michael, Tarter Ralph
School of Pharmacy.
Psychol Addict Behav. 2005 Sep;19(3):243-252. doi: 10.1037/0893-164X.19.3.243.
This study extends prior research (D. Clark, J. Cornelius, L. Kirisci, & R. Tarter, 2005) by determining whether variation in the developmental trajectories of liability to substance use disorder (SUD) is contributed by neurobehavioral disinhibition, parental substance use involvement, and demographic variables. The sample, participants in a long-term prospective investigation, consisted of 351 boys, evaluated at ages 10-12, 12-14, 16, 19, and 22, whose parents either had SUD or no adult psychiatric disorder. Neurobehavioral disinhibition in childhood, in conjunction with parental lifetime substance use/SUD, place the child at very high risk for SUD by age 22 if psychosocial maladjustment progresses in severity in early adolescence. These results indicate that monitoring social adjustment during the transition from childhood to mid-adolescence is important for identifying youth at very high risk for succumbing to SUD by young adulthood.
本研究扩展了先前的研究（D. 克拉克、J. 科尼利厄斯、L. 基里斯奇和R. 塔尔特，2005年），通过确定物质使用障碍（SUD）易感性的发展轨迹变化是否由神经行为抑制、父母物质使用参与情况和人口统计学变量所导致。该样本是一项长期前瞻性调查的参与者，由351名男孩组成，在10 - 12岁、12 - 14岁、16岁、19岁和22岁时接受评估，他们的父母要么患有物质使用障碍，要么没有成人精神疾病。如果心理社会适应不良在青春期早期严重程度不断进展，童年期的神经行为抑制，再加上父母终身物质使用/物质使用障碍，会使孩子在22岁时面临极高的物质使用障碍风险。这些结果表明，在从童年到青春期中期的过渡阶段监测社会适应情况，对于识别在青年期极易患上物质使用障碍的高危青少年很重要。
