Kirisci Levent, Tarter Ralph E, Reynolds Maureen, Vanyukov Michael
Center for Education and Drug Abuse Research, University of Pittsburgh, PA 15261, USA.
Addict Behav. 2006 Apr;31(4):686-96. doi: 10.1016/j.addbeh.2005.05.049. Epub 2005 Jun 16.
Genetic, physiological and psychological investigations have demonstrated that deficient inhibitory regulation amplifies the risk for substance use disorder (SUD). This study extends this line of research by determining the association between childhood neurobehavior disinhibition and decision to desist substance use following prevention intervention during adolescence. The sample consisted of 302 boys who were evaluated at ages 10-12, 12-14, 16, and 19. Results indicated that childhood neurobehavior disinhibition negatively covaried with decision to desist substance use during adolescence. These two variables predicted acceleration of drug consumption frequency during adolescence and DSM-IV diagnosis of SUD by age 19. Decision to desist drug use did not mediate the association between neurobehavior disinhibition and substance use/SUD. The findings indicate that substance abuse prevention would be potentiated by ameliorating childhood neurobehavior disinhibition.
遗传学、生理学和心理学研究表明，抑制调节功能不足会增加物质使用障碍（SUD）的风险。本研究通过确定童年期神经行为抑制与青春期预防干预后停止使用物质的决定之间的关联，扩展了这一研究方向。样本包括302名男孩，他们在10 - 12岁、12 - 14岁、16岁和19岁时接受了评估。结果表明，童年期神经行为抑制与青春期停止使用物质的决定呈负相关。这两个变量预测了青春期药物消费频率的加快以及到19岁时SUD的DSM-IV诊断。停止使用药物的决定并未介导神经行为抑制与物质使用/SUD之间的关联。研究结果表明，改善童年期神经行为抑制将增强物质滥用预防效果。
