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勒夫勒心内膜炎中的心室重构:对治疗决策的影响

Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making.

作者信息

Lofiego Carla, Ferlito Marinella, Rocchi Guido, Biagini Elena, Perugini Enrica, Branzi Angelo, Rapezzi Claudio

机构信息

Institute of Cardiology, University of Bologna, Policlinico S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy.

出版信息

Eur J Heart Fail. 2005 Oct;7(6):1023-6. doi: 10.1016/j.ejheart.2005.06.004. Epub 2005 Sep 26.

Abstract

BACKGROUND

Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis.

METHODS AND RESULTS

We describe 5 patients, including 3 with long-term echocardiographic follow-up, in whom apical obliteration due to fibro-thrombotic thickening of the endocardium showed favorable patterns of evolution. In one patient there was almost complete resolution of the obliterative process with consequently increased effective ventricular volume. In two patients formation of a flow-passage in the fibrocalcific apical 'floor' between the main medioventricular cavity and the apical chamber, leading to a 'double-chambered' left ventricle was observed.

CONCLUSIONS

Medical therapy and appropriate anticoagulation, can induce favorable long-term ventricular remodeling in Loeffler endocarditis.

摘要

背景

关于勒夫勒心内膜炎中心室异常的形态学和功能演变知之甚少。

方法与结果

我们描述了5例患者,其中3例进行了长期超声心动图随访,这些患者因心内膜纤维血栓性增厚导致的心尖闭塞呈现出良好的演变模式。1例患者闭塞过程几乎完全消退,有效心室容积随之增加。在2例患者中,观察到在主中腔室和心尖腔之间的纤维钙化心尖“底部”形成了一个血流通道,导致出现“双腔”左心室。

结论

药物治疗和适当的抗凝可在勒夫勒心内膜炎中诱导良好的长期心室重塑。

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