癫痫患儿的不明原因猝死：一项长达18年随访的队列研究
Sudden unexplained death in children with epilepsy: a cohort study with an eighteen-year follow-up.
作者信息
Weber Peter, Bubl Reinhard, Blauenstein Ursula, Tillmann Bettina U, Lütschg Jürg
机构信息
Department of Neuropaediatrics, Basel University Children's Hospital, Basel, Switzerland.
出版信息
Acta Paediatr. 2005 May;94(5):564-7. doi: 10.1111/j.1651-2227.2005.tb01940.x.
AIM
Sudden unexplained death is a significant cause of mortality in adults with epilepsy. Only a few data exist about this risk in childhood.
METHODS
Cases of sudden unexplained death in epilepsy (SUDEP) up to the age of 18 y occurring at our hospital between 1984 and 2001 were identified. The incidence rate was calculated on the basis of diagnosed epileptics registered with a statutory disability insurance scheme.
RESULTS
Four cases of SUDEP were identified during the 18-y period. The incidence of SUDEP was 4.3 per 10,000 patient-years. All children showed polytherapy-refractory epilepsy, developmental retardation and early-onset epilepsy. Two witnessed cases had shown no previous signs of seizure.
CONCLUSION
SUDEP is rare in childhood. Children with uncomplicated epilepsy seem not to be at risk.
目的
不明原因猝死是成年癫痫患者的一个重要死亡原因。关于儿童期这种风险的数据很少。
方法
确定了1984年至2001年间在我院发生的18岁以下癫痫不明原因猝死（SUDEP）病例。发病率是根据法定残疾保险计划登记的确诊癫痫患者计算的。
结果
在18年期间确定了4例SUDEP病例。SUDEP的发病率为每10000患者年4.3例。所有儿童均表现为多药难治性癫痫、发育迟缓及早发性癫痫。2例有目击者的病例此前未出现癫痫发作迹象。
结论
SUDEP在儿童期很罕见。无并发症的癫痫儿童似乎没有风险。
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