Greene S L, Kerins M, O'Connor N
National Poisons Information Service (London), Guys and St Thomas' NHS Trust, UK.
Emerg Med J. 2005 Oct;22(10):734-7. doi: 10.1136/emj.2005.024968.
Single dose activated charcoal (SDAC) may be an effective method of gastric decontamination when administered to patients within an hour of drug overdose. However, few patients who may benefit from this treatment attend an emergency department within this timeframe. The authors sought to determine the current attitudes of ambulance NHS trusts to recent recommendations that the administration of SDAC should be considered as a prehospital therapy.
A postal questionnaire was used to determine the current level of use of prehospital activated charcoal by ambulance NHS trusts, the incidence of associated complications, and barriers preventing the routine use of prehospital SDAC.
A completed questionnaire was returned by 36 of the 39 ambulance NHS trusts in the UK (response rate 92%). Currently none of the trusts that responded to the questionnaire provides prehospital SDAC as an intervention. The most common barriers to the provision of prehospital SDAC are the current lack of evidence in the medical literature proving it is effective in improving patient outcome and the lack of a recognised protocol for its administration. Other issues included concerns regarding potential complications, ambulance turnaround times, lack of availability of SDAC, and lack of funding.
A lack of published evidence proving efficacy remains the most important factor in preventing the routine administration of SDAC to appropriate patients in the prehospital environment. Further research in this setting is required to determine the usefulness of this therapy.
对于药物过量患者,单剂量活性炭(SDAC)若在服药后一小时内给药,可能是一种有效的胃部净化方法。然而,很少有能从这种治疗中获益的患者在此时间段内前往急诊科就诊。作者试图确定英国国民医疗服务体系(NHS)救护信托机构对近期关于应将SDAC给药视为院前治疗的建议的当前态度。
采用邮寄问卷调查来确定NHS救护信托机构当前院前使用活性炭的情况、相关并发症的发生率以及阻碍院前常规使用SDAC的因素。
英国39个NHS救护信托机构中有36个返回了完整问卷(回复率92%)。目前,回复问卷的信托机构均未将院前SDAC作为一种干预措施提供。提供院前SDAC的最常见障碍是医学文献中目前缺乏证据证明其能有效改善患者预后,以及缺乏公认的给药方案。其他问题包括对潜在并发症的担忧、救护车周转时间、SDAC供应不足以及资金缺乏。
缺乏已发表的疗效证据仍然是阻碍在院前环境中对合适患者常规使用SDAC的最重要因素。需要在这种情况下进行进一步研究以确定这种治疗方法的有效性。