Department of Emergency Medicine, King Fahd Hospital of the University- Imam Abdulrahman Bin Faisal University. Dammam, Kingdom of Saudi Arabia.
Med Arch. 2023 Feb;77(1):64-69. doi: 10.5455/medarh.2023.77.64-69.
Administration of a single-dose activated charcoal (SDAC) is an effective method used for gastric decontamination and for other types of poisoning and overdose. This is only true when given within the first hour of poison ingestion as the effectivity of SDAC reduces over time. In addition, generally, not all patients are able to avail treatment within the specified period. Hence, multi-dose activated charcoal is regarded as a solution to a delayed process, although, no proof outweighs the use of SDAC.
This study aimed to review and assess the adequacy of the past and current use of AC. The author also aimed to offer recommendations believed to be the best method to consider for prehospital care.
The author conducted 6,337 online literature searches for this review, wherein seven papers met eligibility criteria for inclusion and analysis.
In this review, routine administration of AC in poisoning was found not related to the duration of hospital stay nor any other subsequent outcomes following poison ingestion. Further, this review did not establish that administration of AC could improve patient's clinical outcome. Further research and clinical trials is required to determine the efficacy of this therapy to appropriate patients in the prehospital setting.
Activated charcoal can be used to treat highly acute to life-threatening poisoning if it is administered within the first hour of ingestion. Further studies would be necessary to investigate if this would affect clinical outcome..
单次剂量活性炭(SDAC)的给药是一种用于胃内去污染和其他类型中毒和药物过量的有效方法。只有在中毒后 1 小时内给予时才是如此,因为随着时间的推移,SDAC 的有效性会降低。此外,通常并非所有患者都能在规定时间内接受治疗。因此,多剂量活性炭被视为延迟处理的解决方案,尽管没有证据表明 SDAC 的使用更有效。
本研究旨在回顾和评估过去和当前使用 AC 的充分性。作者还旨在提出被认为是考虑院前护理的最佳方法的建议。
作者为此综述进行了 6337 次在线文献检索,其中有 7 篇论文符合纳入和分析的标准。
在本综述中,发现常规给予 AC 治疗中毒与住院时间长短或中毒后任何其他结果无关。此外,本综述并未确定 AC 的给药可以改善患者的临床结果。需要进一步的研究和临床试验来确定这种治疗方法在院前环境中对合适患者的疗效。
如果在摄入后的第一个小时内给予,活性炭可用于治疗高度急性到危及生命的中毒。需要进一步的研究来调查这是否会影响临床结果。