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在感染结核分枝杆菌的豚鼠中使用纳米颗粒包裹的抗结核药物进行口服治疗。

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.

作者信息

Johnson Christine M, Pandey Rajesh, Sharma Sadhna, Khuller G K, Basaraba Randall J, Orme Ian M, Lenaerts Anne J

机构信息

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523-1682, USA.

出版信息

Antimicrob Agents Chemother. 2005 Oct;49(10):4335-8. doi: 10.1128/AAC.49.10.4335-4338.2005.

DOI:10.1128/AAC.49.10.4335-4338.2005
PMID:16189115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1251542/
Abstract

We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.

摘要

我们评估了每10天给药一次的纳米颗粒包裹抗结核药物与每日给予的非包裹药物相比，对豚鼠结核分枝杆菌气溶胶感染的疗效。两种治疗方法均显著降低了细菌数量和肺部组织病理学变化，这表明纳米颗粒给药系统在结核病间歇治疗方面具有潜力。

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本文引用的文献

1
Chemotherapeutic efficacy of poly (DL-lactide-co-glycolide) nanoparticle encapsulated antitubercular drugs at sub-therapeutic dose against experimental tuberculosis.聚（DL-丙交酯-乙交酯）纳米粒包裹的抗结核药物在亚治疗剂量下对实验性结核病的化疗疗效
Int J Antimicrob Agents. 2004 Dec;24(6):599-604. doi: 10.1016/j.ijantimicag.2004.07.010.
2
The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs.在感染结核分枝杆菌的豚鼠中，将牛分枝杆菌卡介苗与结核分枝杆菌72千道尔顿融合多蛋白Mtb72F共同给药，可增强牛分枝杆菌卡介苗的保护作用。
Infect Immun. 2004 Nov;72(11):6622-32. doi: 10.1128/IAI.72.11.6622-6632.2004.
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Infect Immun. 2004 Feb;72(2):1147-9. doi: 10.1128/IAI.72.2.1147-1149.2004.
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