富马酸替诺福韦二吡呋酯与甲磺酸奈非那韦之间不存在药代动力学药物相互作用。
Lack of pharmacokinetic drug interaction between tenofovir disoproxil fumarate and nelfinavir mesylate.
作者信息
Boffito Marta, Pozniak Anton, Kearney Brian P, Higgs Christopher, Mathias Anita, Zhong Lijie, Shah Jaymin
机构信息
PK Research, St. Stephen's Centre, Chelsea and Westminster Hospital, London, UK.
出版信息
Antimicrob Agents Chemother. 2005 Oct;49(10):4386-9. doi: 10.1128/AAC.49.10.4386-4389.2005.
Abstract
A study explored the pharmacokinetics of tenofovir (300 mg administered once daily) and nelfinavir (1,250 mg twice daily) when coadministered in 29 healthy volunteers. Tenofovir, nelfinavir, and M8 pharmacokinetics was unaltered when tenofovir and nelfinavir were coadministered, and tenofovir administration did not affect the M8/nelfinavir area under the concentration-versus-time curve over the dosing interval (AUC(tau)) ratio. No interaction between tenofovir and nelfinavir was observed.
摘要
一项研究探讨了29名健康志愿者同时服用替诺福韦（每日一次，每次300毫克）和奈非那韦（每日两次，每次1250毫克）时的药代动力学。当替诺福韦和奈非那韦同时给药时，替诺福韦、奈非那韦和M8的药代动力学未发生改变，且替诺福韦给药不影响给药间隔期间浓度-时间曲线下面积（AUC(tau)）的M8/奈非那韦比值。未观察到替诺福韦和奈非那韦之间存在相互作用。
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