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本文引用的文献

1
A novel diagnostic marker, p28GANK distinguishes hepatocellular carcinoma from potential mimics.一种新型诊断标志物p28GANK可将肝细胞癌与潜在的类似疾病区分开来。
J Cancer Res Clin Oncol. 2004 Sep;130(9):514-20. doi: 10.1007/s00432-004-0562-y. Epub 2004 Jun 19.
2
Ectopeptidases are differentially expressed in hepatocellular carcinomas.外肽酶在肝细胞癌中存在差异表达。
Int J Oncol. 2004 Mar;24(3):487-95.
3
Diagnostic utility of CD10 in differentiating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration biopsy (FNAB) of the liver.CD10在肝脏细针穿刺活检（FNAB）中鉴别肝细胞癌与转移性癌的诊断效用
Diagn Cytopathol. 2004 Feb;30(2):92-7. doi: 10.1002/dc.10419.
4
Diagnostic value of HepPar1, pCEA, CD10, and CD34 expression in separating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration cytology.HepPar1、pCEA、CD10和CD34表达在细针穿刺细胞学中鉴别肝细胞癌与转移癌的诊断价值
Diagn Cytopathol. 2004 Jan;30(1):1-6. doi: 10.1002/dc.10345.
5
Hepatocyte expressions in hepatocellular carcinomas, gastrointestinal neoplasms, and non-neoplastic gastrointestinal mucosa: its role as a diagnostic marker.肝细胞在肝细胞癌、胃肠道肿瘤及非肿瘤性胃肠道黏膜中的表达：其作为诊断标志物的作用。
J Korean Med Sci. 2003 Dec;18(6):842-8. doi: 10.3346/jkms.2003.18.6.842.
6
Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections.用于肝细胞癌鉴别诊断的Hep par 1抗体染色：使用组织微阵列和传统组织切片检测676例肿瘤。
Mod Pathol. 2003 Feb;16(2):137-44. doi: 10.1097/01.MP.0000052103.13730.20.
7
Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma.肝细胞癌、胆管癌和转移性腺癌的免疫组织化学比较特征
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8
A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver.比较CD10与pCEA、MOC-31及肝细胞用于鉴别肝脏恶性肿瘤。
Mod Pathol. 2002 Dec;15(12):1279-87. doi: 10.1097/01.MP.0000037312.69565.24.
9
Hepatocyte antigen as a marker of hepatocellular carcinoma: an immunohistochemical comparison to carcinoembryonic antigen, CD10, and alpha-fetoprotein.肝细胞抗原作为肝细胞癌的标志物：与癌胚抗原、CD10和甲胎蛋白的免疫组织化学比较
Am J Surg Pathol. 2002 Aug;26(8):978-88. doi: 10.1097/00000478-200208000-00002.
10
Diagnostic utility of the HepPar1 antibody to differentiate hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration samples.HepPar1抗体在细针穿刺样本中鉴别肝细胞癌与转移癌的诊断效用。
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氨肽酶N（CD13）的胆小管免疫染色作为肝细胞癌的诊断标志物。

Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma.

作者信息

Röcken C, Licht J, Roessner A, Carl-McGrath S

机构信息

Department of Pathology, Otto-von-Guericke-University, Leipziger Str. 44, D-39120 Magdeburg, Germany.

出版信息

J Clin Pathol. 2005 Oct;58(10):1069-75. doi: 10.1136/jcp.2005.026328.

DOI:10.1136/jcp.2005.026328
PMID:16189153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1770740/
Abstract

BACKGROUND

Aminopeptidase N (CD13) is expressed in normal and neoplastic liver tissue, where it exhibits a characteristic canalicular pattern (CD13(can)), similar to that seen for CD10 and when antibodies crossreact with biliary glycoprotein I (p-CEA).

AIM

To compare the putative diagnostic use of CD13(can) in differentiating between hepatocellular (HCC) and non-hepatocellular carcinomas metastatic to the liver (non-HCC).

METHODS

A retrospective study comparing 53 HCC specimens with 32 non-HCC specimens. Immunostaining was performed with HepPar1 and antibodies directed against CD10, CD13, p-CEA, and alpha fetoprotein (AFP).

RESULTS

In the HCC group, a canalicular staining pattern was found for CD13, p-CEA, and CD10 in 51, 43, and 33 specimens, respectively. HepPar1 was positive in 29 and AFP in 17 HCC specimens. In the non-HCC group, canalicular immunostaining for CD10 and p-CEA was confined to non-neoplastic liver tissue. One poorly differentiated cholangiocarcinoma showed apical expression of CD13, resembling to some extent CD13(can). Sensitivity and specificity were 96.2% and 97.0%, respectively, for CD13(can), 81.1% and 100% for p-CEA(can), 62.3% and 100%, for CD10(can), 54.7% and 99.9% for HepPar1, and 32.1% and 100% for AFP.

CONCLUSIONS

These results show that CD13(can) is more sensitive in differentiating between HCC and non-HCC than CD10(can), p-CEA(can), HepPar1, and AFP.

摘要

背景

氨肽酶N（CD13）在正常肝脏组织和肿瘤性肝脏组织中均有表达，在其中呈现出一种特征性的胆小管模式（CD13（can）），类似于CD10以及抗体与胆汁糖蛋白I（p-CEA）发生交叉反应时所见到的模式。

目的

比较CD13（can）在鉴别肝细胞癌（HCC）与转移至肝脏的非肝细胞癌（非HCC）中的潜在诊断用途。

方法

一项回顾性研究，比较了53例HCC标本与32例非HCC标本。使用HepPar1以及针对CD10、CD13、p-CEA和甲胎蛋白（AFP）的抗体进行免疫染色。

结果

在HCC组中，分别在51例、43例和33例标本中发现CD13、p-CEA和CD10呈现胆小管染色模式。29例HCC标本中HepPar1呈阳性，17例HCC标本中AFP呈阳性。在非HCC组中，CD10和p-CEA的胆小管免疫染色仅限于非肿瘤性肝脏组织。1例低分化胆管癌显示CD13的顶端表达，在一定程度上类似于CD13（can）。CD13（can）的敏感性和特异性分别为96.2%和97.0%，p-CEA（can）为81.1%和100%，CD10（can）为62.3%和100%，HepPar1为54.7%和99.9%，AFP为32.1%和100%。

结论

这些结果表明，在鉴别HCC与非HCC方面，CD13（can）比CD10（can）、p-CEA（can）、HepPar1和AFP更敏感。