Tong Peter C Y, Ho Chung-Shun, Yeung Vincent T F, Ng Maggie C Y, So Wing-Yee, Ozaki Risa, Ko Gary T C, Ma Ronald C W, Poon Emily, Chan Norman N, Lam Christopher W K, Chan Juliana C N
Department of Medicine and Therapeutics, School of Public Health, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong.
J Clin Endocrinol Metab. 2005 Dec;90(12):6418-23. doi: 10.1210/jc.2005-0228. Epub 2005 Sep 27.
Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES).
Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES.
We conducted a cross-sectional cohort study.
The study was conducted in a university teaching hospital.
Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 +/- 8.1 yr) and 128 men without FH (aged 43.8 +/- 8.5 yr).
Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index > or = 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured.
Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance.
Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.
睾酮和胰岛素样生长因子-I（IGF-I）随年龄增长而下降，这与内脏脂肪沉积有关，内脏脂肪是代谢综合征（MES）的一个组成部分。
睾酮和IGF-I可能与糖尿病家族易感性相互作用，从而增加与MES的关联。
我们进行了一项横断面队列研究。
该研究在一家大学教学医院进行。
研究对象包括179名有糖尿病家族史（FH）的中年男性（年龄39.1±8.1岁）和128名无FH的男性（年龄43.8±8.5岁）。
测量临床特征、采用世界卫生组织标准及亚洲肥胖定义（体重指数≥25kg/m²）的MES发生率，以及总睾酮、IGF-I和高敏C反应蛋白（hs-CRP）的血清水平。
有FH的男性MES发生率高于无FH的男性[39.1%对23.4%（P = 0.004）]。多因素分析显示，吸烟（既往吸烟者和当前吸烟者）、总睾酮水平低、IGF-I水平低但hs-CRP水平升高可解释有FH男性中35%的MES变异。MES发生率随总睾酮和IGF-I三分位数降低以及hs-CRP三分位数升高而增加。在调整年龄和吸烟史后，与无激素和炎症风险因素的受试者相比，具有所有三个风险因素的受试者与MES的风险关联增加了13倍。在无FH的男性中未发现这些风险关联，在这些男性中，只有吸烟（既往和当前）和总睾酮水平低是MES的独立预测因素，可解释14%的变异。
在中国中年男性中，FH、激素异常和高hs-CRP聚集与MES有关。
