Mirzaei Mohammad Reza, Amini Massoud, Aminorroaya Ashraf
Islamic Azad University, Najafabad Branch, Medical Faculty, Iran.
J Res Med Sci. 2012 Jul;17(7):602-6.
Low testosterone, with or without symptoms, reported in diabetic men in some studies. We investigated the prevalence of hypogonadism in Iranian type 2 diabetic men.
Total testosterone (TT) and sex hormone binding globulin (SHBG) concentrations were measured in 247 diabetic men >30 years who had symptoms of androgen deficiency, according to ADAMs questionnaire. The correlation between some parameters and total, free and bioavailable testosterone levels was determined using Pearson correlation coefficient. Free and bioavailable testosterone were calculated by electronic calculator. Four patients were excluded because of high testosterone level, due to unreported androgen use. Overt hypogonadism was defined as total testosterone ≤8 nmol/l or calculated bioavailable testosterone (cBT)≤2.5 nmol/l and borderline hypogonadism was considered as TT 8-12 nmol/l or cBT 2.5-4nmol/l.
The mean and SD of age was 59 (9.3) years. The mean TT, calculated free testosterone (cFT), and cBT and SHBG levels were 4.81 (1.7) nmol/l, 0.11 (0.06) nmol/l, 2.42 (1.17) nmol/l and 36.15 (18.3) nmol/l, respectively. According to TT and cBT, overt hypogonadism observed in 7.4% and 61.6% of men, respectively, and the prevalence of borderline hypogonadism was 9.9% and 36%, respectively. cFT ≤0.16 nmol/l found in 227 diabetic men (96%). Hypogonadism (TT ≤12 nmol/l) was not correlated with obesity, smoking, age,duration of diabetes, blood pressure, and HbA1c.
Hypogonadism is highly prevalent in type 2 diabetes men.
一些研究报道糖尿病男性存在睾酮水平低下的情况，无论有无症状。我们调查了伊朗2型糖尿病男性性腺功能减退的患病率。
根据ADAMs问卷，对247名年龄大于30岁且有雄激素缺乏症状的糖尿病男性测量了总睾酮（TT）和性激素结合球蛋白（SHBG）浓度。使用Pearson相关系数确定一些参数与总睾酮、游离睾酮和生物可利用睾酮水平之间的相关性。游离睾酮和生物可利用睾酮通过电子计算器计算得出。4名患者因睾酮水平高（未报告使用雄激素）被排除。显性性腺功能减退定义为总睾酮≤8 nmol/l或计算得出的生物可利用睾酮（cBT）≤2.5 nmol/l，边缘性性腺功能减退被认为是TT为8 - 12 nmol/l或cBT为2.5 - 4 nmol/l。
年龄的平均值和标准差为59（9.3）岁。总睾酮、计算得出的游离睾酮（cFT）、cBT和SHBG水平的平均值分别为4.81（1.7）nmol/l、0.11（0.06）nmol/l、2.42（1.17）nmol/l和36.15（18.3）nmol/l。根据TT和cBT，分别有7.4%和61.6%的男性存在显性性腺功能减退，边缘性性腺功能减退的患病率分别为9.9%和36%。在227名糖尿病男性（96%）中发现cFT≤0.16 nmol/l。性腺功能减退（TT≤12 nmol/l）与肥胖、吸烟、年龄、糖尿病病程、血压和糖化血红蛋白无关。
性腺功能减退在2型糖尿病男性中非常普遍。
