Abud Tania Mara Vilela, Braz José Reinaldo Cerqueira, Martins Regina Helena Garcia, Gregório Elisa Aparecida, Saldanha João Carlos, Raiza Ana Carolina Pasquini
Department of Anesthesiology, School of Medicine, UNESP, District of Rubião Júnior - P.O. Box 530, Zip Code 18618-970 - Botucatu, SP - Brazil.
Can J Anaesth. 2005 Oct;52(8):878-82. doi: 10.1007/BF03021785.
To determine, in dogs anesthetized with nitrous oxide (N2O), (whether the endotracheal tube (ETT) cuffed with a Lanz pressure regulating valve decreases the tracheal consequences of tracheal intubation.
Sixteen mixed-breed dogs were allocated to two groups according to the ETT used: Control group (n = 8) - Rüsch ETT, and Lanz group (n = 8) - ETT with Lanz pressure regulating valve. The ETT cuffs in both groups were inflated with air to an intracuff pressure of 30 cm H2O. Anesthesia was induced and maintained with pentobarbitone and N2O (1.5 L x min(-1)) and O2 (1 L x min(-1)). ETT cuff pressures were measured before (control) and 60, 120, and 180 min during N2O administration. The dogs were sacrificed, and biopsy specimens from four predetermined areas of the tracheal mucosa in contact with the ETT were collected for light and scanning electron microscopy (SM) examination.
Cuff pressures in the Control group were higher than in the Lanz group at all time points studied (P < 0.001), with an increase over time only in the Control group (P < 0.001). Median neutrophilic inflammatory infiltration values of the epithelial surface, and in the subepithelial layer in contact with the cuff, were higher in the Control group as compared to the Lanz group (3.0 vs 1.0 and 3.0 vs 1.5 respectively) (P < 0.05). On SM examination, median histological grades were higher in the Control group compared to Lanz group (2.9 vs 1.9 respectively), (P < 0.05).
The Lanz ETT decreases tracheal mucosal injury in dogs.
在使用氧化亚氮（N₂O）麻醉的犬中，确定带有兰茨压力调节阀的气管内导管（ETT）是否能减轻气管插管对气管的影响。
根据所使用的ETT将16只杂种犬分为两组：对照组（n = 8）——使用鲁施ETT；兰茨组（n = 8）——使用带有兰茨压力调节阀的ETT。两组的ETT套囊均用空气充气至套囊内压力30 cm H₂O。用戊巴比妥和N₂O（1.5 L×min⁻¹）及O₂（1 L×min⁻¹）诱导并维持麻醉。在N₂O给药前（对照）以及给药期间的60、120和180分钟测量ETT套囊压力。处死犬后，收集气管黏膜与ETT接触的四个预定区域的活检标本，用于光镜和扫描电子显微镜（SEM）检查。
在所有研究时间点，对照组的套囊压力均高于兰茨组（P < 0.001），且仅对照组的套囊压力随时间增加（P < 0.001）。与兰茨组相比，对照组上皮表面以及与套囊接触的上皮下层的中性粒细胞炎性浸润值中位数更高（分别为3.0对1.0和3.0对1.5）（P < 0.05）。在SEM检查中，对照组的组织学分级中位数高于兰茨组（分别为2.9对1.9）（P < 0.05）。
兰茨ETT可减轻犬的气管黏膜损伤。
