Tomić K, Tomas D, Tomasković I, Kos M, Belicza M, Kruslin B
General Hospital Josip Bencević, Slavonski Brod, Croatia.
Virchows Arch. 2006 Jan;448(1):24-8. doi: 10.1007/s00428-005-0090-4. Epub 2005 Sep 28.
Arterial fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic, occlusive condition of the systemic arteries, most frequently affecting renal arteries. Renal cell carcinoma (RCC) might be associated with arterial hypertension; however, there are no data in the literature regarding the relationship between RCC and associated renal artery changes. We analyzed a consecutive series of 57 (35 male and 22 female) patients aging from 35 to 79 years (mean 58.9 years) who underwent nephrectomy due to RCC in the year 2003. The patients had RCC measuring from 2 to 16 cm (mean 7.1 cm). Specimens were routinely fixed, embedded in paraffin, cut, and stained with hematoxylin and eosin, Mallory trichrome method, and orcein. Renal arteries of 26 patients (20 male, 6 female) showed no changes. In these patients, RCC measured 2.5-11 cm in largest diameter (mean 6.6 cm). In 24 patients (10 male, 14 female), renal arteries showed FMD. RCCs in these patients measured between 2 and 16 cm (mean 8.0 cm). Seven patients had atherosclerotic changes in renal arteries. In this series, FMD was found in a significant proportion of patients with RCC, mainly in women. The cause of such changes and their relationship with RCC and systemic hypertension should be further analyzed.
动脉纤维肌发育不良（FMD）是一种全身性动脉的非炎性、非动脉粥样硬化性闭塞性疾病，最常累及肾动脉。肾细胞癌（RCC）可能与动脉高血压有关；然而，文献中尚无关于RCC与相关肾动脉改变之间关系的数据。我们分析了2003年因RCC接受肾切除术的连续57例患者（35例男性和22例女性），年龄在35至79岁之间（平均58.9岁）。这些患者的RCC大小为2至16厘米（平均7.1厘米）。标本常规固定、石蜡包埋、切片，并用苏木精和伊红、马洛里三色法和orcein染色。26例患者（20例男性，6例女性）的肾动脉未显示改变。在这些患者中，RCC最大直径为2.5至11厘米（平均6.6厘米）。24例患者（10例男性，14例女性）的肾动脉显示有FMD。这些患者的RCC大小在2至16厘米之间（平均8.0厘米）。7例患者的肾动脉有动脉粥样硬化改变。在本系列中，相当一部分RCC患者发现有FMD，主要是女性。应进一步分析此类改变的原因及其与RCC和全身性高血压的关系。
