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酸水解/萃取乙酰化后尿中酚类共轭物的气相色谱测定

Gas chromatographic determination of urinary phenol conjugates after acid hydrolysis/extractive acetylation.

作者信息

Weber L

机构信息

National Institute of Occupational Health, Budapest, Hungary.

出版信息

J Chromatogr. 1992 Feb 14;574(2):349-51. doi: 10.1016/0378-4347(92)80051-q.

DOI:10.1016/0378-4347(92)80051-q
PMID:1618971
Abstract

Phenolic metabolites of inhaled aromatic solvent vapours were liberated by acid hydrolysis of their urinary conjugates. Steam distillation enhanced by salting-out with MgSO4 gave good recoveries. After extractive acetylation, the derivatives of all cresols and xylenols were completely separated on a Se-54 capillary column. The overall recoveries of urinary phenols relative to the internal standard, 3-chlorophenol, were in the range 92-99%.

摘要

吸入的芳香族溶剂蒸气的酚类代谢物通过其尿结合物的酸水解而释放出来。用硫酸镁盐析增强的水蒸气蒸馏可实现良好的回收率。萃取乙酰化后，所有甲酚和二甲酚的衍生物在Se-54毛细管柱上完全分离。相对于内标物3-氯酚，尿酚的总回收率在92%-99%范围内。

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