Taïeb A, Bassan-Andrieu L, Maleville J
Dermatology Service, Hôpital des Enfants, Bordeaux, France.
J Am Acad Dermatol. 1992 Jul;27(1):55-60. doi: 10.1016/0190-9622(92)70156-a.
Among sterile pustulosis in childhood, a pruritic relapsing eosinophilic variant beginning in infancy and located mostly in the scalp was first described as eosinophilic pustular folliculitis in infancy by Lucky and colleagues in 1984.
Our purpose is to describe such a condition in five boys and one girl and comment on differential diagnosis and relation with Ofuji's disease.
This is a clinicopathologic study.
All patients had scalp pustules beginning in infancy or early childhood that were unresponsive to antibiotic therapy. Lesions also occurred on other areas but the scalp was the major site of involvement. Although secondary infection was demonstrated in one case, the lesions were primarily sterile. Smears of pustules showed a variable proportion of eosinophils. Histopathologic findings suggested a major role for eosinophils in this disorder because dermal eosinophilia was noted in all patients. The inflammatory pattern was not similar to Ofuji's disease. Transient blood eosinophilia was recorded in five patients. Topical steroids relieved inflammatory episodes. Dapsone was tried in one case with apparent benefit.
Eosinophilic pustulosis of the scalp in childhood is a self-limited disease that can be relieved by topical steroids.
在儿童无菌性脓疱病中，一种始于婴儿期、主要位于头皮的瘙痒性复发性嗜酸性粒细胞变体，于1984年被拉基及其同事首次描述为婴儿期嗜酸性脓疱性毛囊炎。
我们的目的是描述5名男孩和1名女孩的这种病症，并对鉴别诊断以及与小藤病的关系进行评论。
这是一项临床病理研究。
所有患者在婴儿期或幼儿期开始出现头皮脓疱，对抗生素治疗无反应。皮损也出现在其他部位，但头皮是主要受累部位。尽管有1例显示有继发感染，但皮损主要为无菌性。脓疱涂片显示嗜酸性粒细胞比例不一。组织病理学结果提示嗜酸性粒细胞在该疾病中起主要作用，因为所有患者均有真皮嗜酸性粒细胞浸润。炎症模式与小藤病不同。5例患者出现短暂性血液嗜酸性粒细胞增多。外用类固醇可缓解炎症发作。1例试用氨苯砜，有明显疗效。
儿童头皮嗜酸性脓疱病是一种自限性疾病，外用类固醇可缓解病情。
