García-Patos V, Pujol R M, de Moragas J M
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Dermatology. 1994;189(2):133-8. doi: 10.1159/000246816.
Eosinophilic pustular folliculitis (EPF) is a cutaneous inflammatory follicular disorder of unknown etiology. The diagnosis is established on the basis of clinical and histopathologic features. In only a few instances has EPF been described in children.
We describe the clinical and histopathologic features of a recurrent follicular eosinophilic pustular eruption involving the scalp in 2 children. Previously reported cases of EPF in childhood below 14 years of age are reviewed.
Two patients (9-month-old and 6-month-old boys) presented current crops of follicular pustules on the scalp of 4 and 5 months' evolution. The lesions resolved spontaneously without scarring. Histopathologic examination revealed an acute follicular inflammatory infiltrate with abundant eosinophils. Scraping from the lesions showed abundant eosinophils in 1 case. A peripheral eosinophilia was also detected in both patients.
EPF in children below 1 year of age seems to represent a unique disorder bearing distinctive clinical (constant involvement of the scalp), evolutive (self-healing recurrent crops) and prognostic (the lesions may last until 3 years of age) features. A possible relationship between this disorder and other idiopathic pustular dermatoses of early childhood (especially with infantile acropustulosis) is suggested.
嗜酸性脓疱性毛囊炎（EPF）是一种病因不明的皮肤炎性毛囊疾病。其诊断基于临床和组织病理学特征。仅有少数儿童期EPF的病例报道。
我们描述了2例儿童复发性毛囊嗜酸性脓疱性皮疹累及头皮的临床和组织病理学特征。回顾了先前报道的14岁以下儿童期EPF病例。
2例患者（分别为9个月大及6个月大的男孩）头皮出现当前一批毛囊脓疱，病程分别为4个月和5个月。皮损自行消退，无瘢痕形成。组织病理学检查显示急性毛囊炎性浸润，伴有大量嗜酸性粒细胞。1例患者皮损刮片显示大量嗜酸性粒细胞。2例患者均检测到外周血嗜酸性粒细胞增多。
1岁以下儿童的EPF似乎是一种独特的疾病，具有独特的临床（头皮持续受累）、演变（自愈性复发性皮疹）和预后（皮损可持续至3岁）特征。提示该疾病与其他儿童期特发性脓疱性皮肤病（尤其是婴儿肢端脓疱病）可能存在关联。
