Brodtkorb Eylert, Steinlein Ortrud K, Sand Trond
Department of Neurology and Clinical Neurophysiology, St. Olav's Hospital, Trondheim, Norway.
Epilepsia. 2005 Oct;46(10):1692-4. doi: 10.1111/j.1528-1167.2005.00271.x.
To investigate auditory processing with cortical long-latency auditory evoked potentials (AEPs) in patients with autosomal dominant lateral temporal lobe epilepsy (ADTLE).
Eight patients with LGI1-related ADTLE belonging to a family with predominantly aphasic seizures were studied. Sixty-five individuals without epilepsy served as controls. AEPs (N1-P2 amplitudes) to binaural tones were recorded over the left and the right hemispheres. Brainstem auditory evoked potentials (BAEPs) to monaural rarefaction clicks also were analyzed. Group differences were statistically assessed with Student's t test and repeated-measures analysis of variance.
Left N1-P2 AEP amplitudes were moderately reduced in ADTLE patients (p = 0.005). No group differences in BAEP were found, indicating unaffected cochlear system and auditory brainstem pathways.
A moderate, but highly significant reduction in N1-P2 AEP amplitudes over the left hemisphere was demonstrated in patients with ADTLE. This finding corresponds to the cardinal symptom of aphasia in this family, and also to the generally prevailing left-sided EEG abnormalities in this condition. The background for this electrophysiologic lateralization in LGI1-related epilepsy is unknown. It may be related to a specific function of LGI1 in the dominant hemisphere.
利用皮质长潜伏期听觉诱发电位（AEP）研究常染色体显性遗传性外侧颞叶癫痫（ADTLE）患者的听觉处理能力。
对8例与LGI1相关的ADTLE患者进行研究，这些患者来自一个以失语性发作为主要特征的家系。65名无癫痫的个体作为对照。记录左右半球对双耳纯音的AEP（N1-P2波幅）。还分析了对单耳疏波短声的脑干听觉诱发电位（BAEP）。采用学生t检验和重复测量方差分析对组间差异进行统计学评估。
ADTLE患者左侧N1-P2 AEP波幅中度降低（p = 0.005）。未发现BAEP有组间差异，表明耳蜗系统和听觉脑干通路未受影响。
ADTLE患者左侧半球N1-P2 AEP波幅有中度但高度显著的降低。这一发现与该家系失语的主要症状相符，也与这种情况下普遍存在的左侧脑电图异常相符。LGI1相关癫痫中这种电生理偏侧化的背景尚不清楚。它可能与LGI1在优势半球的特定功能有关。
