缓解期心境障碍患者全血中胶质细胞源性神经营养因子（GDNF）水平降低。
Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders.
作者信息
Takebayashi Minoru, Hisaoka Kazue, Nishida Akira, Tsuchioka Mami, Miyoshi Izuru, Kozuru Tosirou, Hikasa Satoshi, Okamoto Yasumasa, Shinno Hideto, Morinobu Shigeru, Yamawaki Shigeto
机构信息
Institute of Clinical Research, Department of Psychiatry, National Hospital Organization (NHO) Kure Medical Center, Kure, and Department of Neuroscience, Yamaguchi University School of Medicine, Japan.
出版信息
Int J Neuropsychopharmacol. 2006 Oct;9(5):607-12. doi: 10.1017/S1461145705006085. Epub 2005 Sep 28.
Recent post-mortem and imaging studies provide evidence for a glial reduction in different brain areas in mood disorders. This study was aimed to test whether glial cell line-derived neurotrophic factor (GDNF), a member of transforming growth factor (TGF)-beta superfamily, in blood levels was associated with mood disorders. We measured GDNF and TGF-beta levels in whole blood in remitted patients with mood disorders [n=56; major depressive disorders (MDD) 39, bipolar disorders (BD) 17] and control subjects (n=56). GDNF and TGF-beta were assayed with the sandwich ELISA method. Total GDNF levels were significantly lower in MDD and in BD than in control subjects (MDD, p=0.0003; BD, p=0.018), while no significant difference in total TGF-beta1 or total TGF-beta2 levels was found in these groups. Our study suggests that lower GDNF levels might be involved in the pathophysiology of mood disorders, although this preliminary study has several limitations.
近期的尸检和影像学研究为情绪障碍患者不同脑区的胶质细胞减少提供了证据。本研究旨在测试血液中转化生长因子（TGF）-β超家族成员胶质细胞源性神经营养因子（GDNF）水平是否与情绪障碍有关。我们测量了缓解期情绪障碍患者（n = 56；重度抑郁症（MDD）39例，双相情感障碍（BD）17例）和对照受试者（n = 56）全血中的GDNF和TGF-β水平。采用夹心ELISA法检测GDNF和TGF-β水平；MDD组和BD组的总GDNF水平显著低于对照组（MDD，p = 0.0003；BD组，p = 0.018），而这些组中的总TGF-β1或总TGF-β2水平未发现显著差异。我们的研究表明GDNF水平降低可能参与了情绪障碍的病理生理过程，尽管这项初步研究存在一些局限性。
Zotero 插件