Çelebi Zeynep, Yazıcı Esra, Güzel Erdoğan Derya, Davutoglu Onur, Yazıcı Ahmet Bulent
Medical Faculty Department of Psychiatry, Sakarya University, Sakarya, Türkiye.
Medical Faculty Department of Physiology, Sakarya University, Sakarya, Türkiye.
BMC Psychiatry. 2025 Jan 20;25(1):53. doi: 10.1186/s12888-025-06469-0.
Klotho and neurotrophic factors, including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF), have been shown to play a role in cognitive functions. However, these molecules have not been investigated in bipolar disorder simultaneously to assess the interactions among them and their relationships with cognitive functions. This study investigated the relationships among cognitive function, klotho, and neurotrophic factors in patients with bipolar disorder in the remission period.
Male, bipolar disorder (BD) patients (patient group, n = 48) in the remission period and healthy volunteers (control group, n = 48) were included in the study. The Stroop test and Wechsler Memory Scale-Visual Production Subtest were applied, and the serum levels of Klotho, BDNF, GDNF, and NGF were measured with an ELISA reader.
The klotho protein levels (0.12 ± 0.15 and 0.17 ± 0.16) and NGF levels (34.36 ± 41.99 and 48.54 ± 41.06) in the patient group were significantly lower than those in the control group (Z = -3.071, p = 0.002 and Z = -2.217, p = 0.027, respectively). In the patient group, there was a positive correlation between the klotho and NGF levels (p = 0.003, r = 0.413), and a negative correlation was detected between the NGF and GDNF levels (p = 0.013, r = -0.355). Klotho and NGF were predictors of Weshler 40-min test results (adjusted R2 = 0.467), and Klotho and BDNF were predictors of Stroop test colour word reading time (adjusted R2 = 0.391) with other variables.
In BD patients, klotho, BDNF, GDNF and NGF are associated with cognitive functions and exhibit different characteristics from those of the control group. Nevertheless, the differences related to these molecules seem to be associated with a regulatory system rather than merely an increase or decrease in serum levels.
已有研究表明，α-klotho和神经营养因子，包括脑源性神经营养因子（BDNF）、神经生长因子（NGF）和胶质细胞系源性神经营养因子（GDNF），在认知功能中发挥作用。然而，尚未对双相情感障碍患者同时研究这些分子，以评估它们之间的相互作用及其与认知功能的关系。本研究调查了缓解期双相情感障碍患者认知功能、α-klotho和神经营养因子之间的关系。
本研究纳入了缓解期男性双相情感障碍（BD）患者（患者组，n = 48）和健康志愿者（对照组，n = 48）。应用Stroop测试和韦氏记忆量表视觉再生分测验，并使用酶标仪测量血清中α-klotho、BDNF、GDNF和NGF的水平。
患者组的α-klotho蛋白水平（0.12±0.15和0.17±0.16）和NGF水平（34.36±41.99和48.54±41.06）显著低于对照组（Z = -3.071，p = 0.002和Z = -2.217，p = 0.027）。在患者组中，α-klotho与NGF水平呈正相关（p = 0.003，r = 0.413），NGF与GDNF水平呈负相关（p = 0.013，r = -0.355）。α-klotho和NGF是韦氏40分钟测试结果的预测因子（调整后R2 = 0.467），α-klotho和BDNF是Stroop测试颜色词阅读时间的预测因子（调整后R2 = 0.391），其他变量也有影响。
在双相情感障碍患者中，α-klotho、BDNF、GDNF和NGF与认知功能相关，且表现出与对照组不同的特征。然而，与这些分子相关的差异似乎与一个调节系统有关，而不仅仅是血清水平的升高或降低。
